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[Platform]: Target prioritisation links updated #299

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Nov 23, 2023
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Original file line number Diff line number Diff line change
Expand Up @@ -35,7 +35,7 @@ const maxClinicalTrialPhase: Column = {
aggregation: aggregations.precedence,
sectionId: "knownDrugs",
description: "Target is in clinical trials for any indication",
docsLink: "http://home.opentargets.org/aotf-documentation#target-in-clinic",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#target-in-clinic",
};

const isInMembrane: Column = {
Expand All @@ -44,7 +44,7 @@ const isInMembrane: Column = {
aggregation: aggregations.tractability,
sectionId: "subcellularLocation",
description: "Target is annotated to be located in the cell membrane",
docsLink: "http://home.opentargets.org/aotf-documentation#membrane-protein",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#membrane-protein",
};

const isSecreted: Column = {
Expand All @@ -53,7 +53,7 @@ const isSecreted: Column = {
aggregation: aggregations.tractability,
sectionId: "subcellularLocation",
description: "Target is annotated to be secreted",
docsLink: "http://home.opentargets.org/aotf-documentation#secreted-protein",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#secreted-protein",
};

const hasLigand: Column = {
Expand All @@ -62,7 +62,7 @@ const hasLigand: Column = {
aggregation: aggregations.tractability,
sectionId: "tractability",
description: "Target binds a specific ligand",
docsLink: "http://home.opentargets.org/aotf-documentation#ligand-binder",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#ligand-binder",
};

const hasSmallMoleculeBinder: Column = {
Expand All @@ -71,7 +71,7 @@ const hasSmallMoleculeBinder: Column = {
aggregation: aggregations.tractability,
sectionId: "tractability",
description: "Target binds a small molecule",
docsLink: "http://home.opentargets.org/aotf-documentation#small-molecule-binder",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#small-molecule-binder",
};

const hasPocket: Column = {
Expand All @@ -80,7 +80,7 @@ const hasPocket: Column = {
aggregation: aggregations.tractability,
sectionId: "tractability",
description: "Target has predicted pockets",
docsLink: "http://home.opentargets.org/aotf-documentation#predicted-pockets",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#predicted-pockets",
};

const mouseOrthologMaxIdentityPercentage: Column = {
Expand All @@ -89,7 +89,7 @@ const mouseOrthologMaxIdentityPercentage: Column = {
aggregation: aggregations.doability,
sectionId: "compGenomics",
description: "Mouse ortholog maximum identity percentage",
docsLink: "http://home.opentargets.org/aotf-documentation#mouse-ortholog-identity",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#mouse-ortholog-identity",
};

const hasHighQualityChemicalProbes: Column = {
Expand All @@ -98,7 +98,7 @@ const hasHighQualityChemicalProbes: Column = {
aggregation: aggregations.doability,
sectionId: "chemicalProbes",
description: "Availability of high quality chemical probes for the target",
docsLink: "http://home.opentargets.org/aotf-documentation#chemical-probes",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#chemical-probes",
};

const mouseKOScore: Column = {
Expand All @@ -107,7 +107,7 @@ const mouseKOScore: Column = {
aggregation: aggregations.safety,
sectionId: "mousePhenotypes",
description: "Availability of mouse knockout models for the target",
docsLink: "http://home.opentargets.org/aotf-documentation#mouse-ko",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#mouse-models",
};

const geneticConstraint: Column = {
Expand All @@ -116,7 +116,7 @@ const geneticConstraint: Column = {
aggregation: aggregations.safety,
sectionId: "geneticConstraint",
description: "Relative genetic constraint in natural populations derived from GnomAD",
docsLink: "http://home.opentargets.org/aotf-documentation#genetic-constraint",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#genetic-constraint",
};

const geneEssentiality: Column = {
Expand All @@ -125,7 +125,7 @@ const geneEssentiality: Column = {
aggregation: aggregations.safety,
sectionId: "depMapEssentiality",
description: "Gene is defined as core essential by the DepMap portal",
docsLink: "http://home.opentargets.org/aotf-documentation#gene-essentiality",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#gene-essentiality",
};

const hasSafetyEvent: Column = {
Expand All @@ -134,7 +134,7 @@ const hasSafetyEvent: Column = {
aggregation: aggregations.safety,
sectionId: "safety",
description: "Target associated with a curated adverse event",
docsLink: "http://home.opentargets.org/aotf-documentation#known-adverse-events",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#known-adverse-events",
};

const isCancerDriverGene: Column = {
Expand All @@ -143,7 +143,7 @@ const isCancerDriverGene: Column = {
aggregation: aggregations.safety,
sectionId: "cancerHallmarks",
description: "Target is classified as an Oncogene and/or Tumor Suppressor Gene",
docsLink: "http://home.opentargets.org/aotf-documentation#cancer-driver-gene",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#cancer-driver-gene",
};

const paralogMaxIdentityPercentage: Column = {
Expand All @@ -152,7 +152,7 @@ const paralogMaxIdentityPercentage: Column = {
aggregation: aggregations.safety,
sectionId: "compGenomics",
description: "Paralog maximum identity percentage",
docsLink: "http://home.opentargets.org/aotf-documentation#paralogues",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#paralogues",
};

const tissueSpecificity: Column = {
Expand All @@ -161,7 +161,7 @@ const tissueSpecificity: Column = {
aggregation: aggregations.safety,
sectionId: "expressions",
description: "HPA category types of elevated expression across tissues for the target",
docsLink: "http://home.opentargets.org/aotf-documentation#tissue-specificity",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#tissue-specificity",
};

const tissueDistribution: Column = {
Expand All @@ -170,7 +170,7 @@ const tissueDistribution: Column = {
aggregation: aggregations.safety,
sectionId: "expressions",
description: "HPA category types of detectable expression across tissues for the target",
docsLink: "http://home.opentargets.org/aotf-documentation#tissue-distribution",
docsLink: "https://platform-docs.opentargets.org/target-prioritisation#tissue-distribution",
};

const cols: Column[] = [
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