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[DATALAD RUNCMD] Get latest validation reports with a summary
=== Do not change lines below === { "chain": [], "cmd": "duct dandisets-linkml-status --include-unpublished --dandi-instance dandi -l INFO", "exit": 0, "extra_inputs": [], "inputs": [], "outputs": [], "pwd": "." } ^^^ Do not change lines above ^^^
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"url": "https://dandiarchive.org/dandiset/001253/draft", | ||
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description: "Machine learning research has achieved large performance gains on a | ||
wide range of tasks by expanding the learning target from mean rewards to entire | ||
probability distributions of rewards \u2014 an approach known as distributional | ||
reinforcement learning (RL). The mesolimbic dopamine system is thought to underlie | ||
RL in the mammalian brain by updating a representation of mean value in the striatum, | ||
but little is known about whether, where, and how neurons in this circuit encode | ||
information about higher-order moments of reward distributions. To fill this gap, | ||
we used high-density probes (Neuropixels) to record striatal activity from mice | ||
performing a classical conditioning task in which reward mean, reward variance, | ||
and stimulus identity were independently manipulated. In contrast to traditional | ||
RL accounts, we found robust evidence for abstract encoding of variance in the striatum. | ||
Remarkably, chronic ablation of dopamine inputs disorganized these distributional | ||
representations in the striatum without interfering with mean value coding. Two-photon | ||
calcium imaging and optogenetics revealed that the two major classes of striatal | ||
medium spiny neurons \u2014 D1 and D2 MSNs \u2014 contributed to this code by preferentially | ||
encoding the right and left tails of the reward distribution, respectively. We synthesize | ||
these findings into a new model of the striatum and mesolimbic dopamine that harnesses | ||
the opponency between D1 and D2 MSNs to reap the computational benefits of distributional | ||
RL. " | ||
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[] |
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[] |
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