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<!DOCTYPE HTML>
<html>
<head>
<title>Serrano-Pozo Lab</title>
<meta charset="utf-8" />
<meta name="viewport" content="width=device-width, initial-scale=1, user-scalable=no"/>
<link rel="shortcut icon" type="image/svg" href="images/favicon.ico"/>
<link rel="stylesheet" href="assets/css/main.css"/>
<link rel="stylesheet" href="assets/css/custom.css"/>
<noscript><link rel="stylesheet" href="assets/css/noscript.css"/></noscript>
</head>
<body class="is-preload">
<!-- Page Wrapper -->
<div id="page-wrapper">
<!-- Header -->
<header id="header" class="alt">
<h1><a href="https://www.serranopozolab.org">Serrano-Pozo Lab</a></h1>
<nav>
<a href="#menu">Menu</a>
</nav>
</header>
<!-- Menu -->
<nav id="menu">
<div class="inner">
<h2>Menu</h2>
<ul class="links">
<li><a href="https://www.serranopozolab.org">Home</a></li>
<li><a href="https://www.serranopozolab.org/research">Research</a></li>
<li><a href="https://www.serranopozolab.org/team">Team</a></li>
<li><a href="https://www.serranopozolab.org/location">Location</a></li>
<li><a href="https://www.serranopozolab.org/publications">Publications</a></li>
<li><a href="#contact">Contact</a></li>
</ul>
<a href="#" class="close">Close</a>
</div>
</nav>
<!-- Banner -->
<section id="banner">
<div class="inner">
<!-- <div class="logo"><span class="icon solid fa-flask"></span></div> -->
<h2 style = "margin-top: 3em">Serrano-Pozo Lab</h2>
<p>Researching the role of glia in Alzheimer's disease</p>
</div>
</section>
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<section id="wrapper">
<!-- One -->
<section id="one" class="wrapper spotlight style1">
<div class="inner">
<a href="#" class="image"><img src="images/research.jpg" alt="" /></a>
<div class="content">
<h2 class="major">Research</h2>
<p>We are interested in the mechanisms leading to Alzheimer's disease, with a special emphasis on the role of <i>APOE</i> and glial cells.</p>
<a href="https://www.serranopozolab.org/research" class="special">Learn more</a>
</div>
</div>
</section>
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<a href="#" class="image"><img src="images/lab_coat.PNG" alt="" /></a>
<div class="content">
<h2 class="major">Team</h2>
<p>Led by Dr. Alberto Serrano-Pozo, we are an interdisciplinary team dedicated to ensuring a brighter future for patients with neurodegenerative diseases.</p>
<a href="https://www.serranopozolab.org/team" class="special">Learn more</a>
</div>
</div>
</section>
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<a href="#" class="image"><img src="images/mass_general.PNG" alt="" /></a>
<div class="content">
<h2 class="major">Location</h2>
<p>We are located in Charlestown, MA within the MassGeneral Institute for Neurodegenerative Disease (MIND) at Massachusetts General Hospital and Harvard Medical School.</p>
<a href="https://www.serranopozolab.org/location" class="special">Learn more</a>
</div>
</div>
</section>
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<section id="four" class="wrapper alt style1">
<div class="inner">
<h2 class="major">Featured Work</h2>
<p>Please see some of the most recent publications and projects from our group below.</p>
<section class="features">
<article>
<a href="#" class="image"><img src="images/astrocyte_atlas.PNG" alt="" /></a>
<h3 class="major">Astrocyte Atlas</h3>
<p>A public database of astrocyte immunohistochemical studies in postmortem Alzheimer's disease brains.</p>
<a href="https://www.astrocyteatlas.org" class="special" target="_blank" rel="noopener noreferrer">Learn more</a>
</article>
<article>
<a href="#" class="image"><img src="images/consensus_statement.PNG" alt="" /></a>
<h3 class="major">Consensus Statement</h3>
<p>Recently published in <i>Nature Neuroscience</i>, this consensus statement advocates for increased nuance in reactive astrocyte classification.</p>
<a href="https://dx.doi.org/10.1038%2Fs41593-020-00783-4" class="special" target="_blank" rel="noopener noreferrer">Learn more</a>
</article>
<article>
<a href="#" class="image"><img src="images/lancet_neurology.PNG" alt="" /></a>
<h3 class="major"><i>APOE</i> and Alzheimer's</h3>
<p>This review, published in <i>The Lancet Neurology</i>, charts the progress in the effort to design <i>APOE</i>-based therapies for Alzheimer's disease.</p>
<a href="https://doi.org/10.1016/s1474-4422(20)30412-9" class="special" target="_blank" rel="noopener noreferrer">Learn more</a>
</article>
<article>
<a href="#" class="image"><img src="images/journal_neuroinflammation.PNG" alt="" /></a>
<h3 class="major">Context Dependent Reaction</h3>
<p>Published in the <i>Journal of Neuroinflammation</i>, this meta-analysis of mouse transcriptomics indicates that astrocyte reaction is context-dependent.</p>
<a href="https://doi.org/10.1186/s12974-020-01898-y" class="special" target="_blank" rel="noopener noreferrer">Learn more</a>
</article>
</section>
<ul class="actions">
<li><a href="https://www.serranopozolab.org/publications" class="button">Browse All Publications</a></li>
</ul>
</div>
</section>
</section>
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<section id="footer">
<div class="inner">
<h2 class="major" id="contact">Contact</h2>
<p>Interested in our work? Please don't hesitate to reach out. We look forward to hearing from you.</p>
<ul class="contact">
<li class="icon solid fa-home">
MassGeneral Institute for Neurodegenerative Disease<br/>
114 16th Street, Suite 2012<br/>
Charlestown, MA 02129
</li>
<li class="icon solid fa-phone">(617) 643-0870</li>
<li class="icon solid fa-envelope"><a href="mailto:aserrano1@mgh.harvard.edu">aserrano1@mgh.harvard.edu</a></li>
</ul>
<ul class="copyright">
<li>Website developed by Ayush Noori.</li>
<li style="float: right; border-left: none; padding-left: 0em;"><a href="https://www.massgeneral.org/" class="image" target="_blank" rel="noopener noreferrer"><img src="images/MGH_logo.svg" style="height: 6em;" alt=""/></a></li>
<li style="float: right; border-left: none; padding-left: 0em;"><a href="https://hms.harvard.edu/" class="image" target="_blank" rel="noopener noreferrer"><img src="images/HMS_logo.svg" style="height: 6em;" alt=""/></a></li>
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