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rcedgar authored May 22, 2024
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Reseek is a novel protein structure alignment algorithm which doubles sensitivity in protein homolog detection
compared to state-of-the-art methods including DALI, TM-align and Foldseek with improved speed over Foldseek, the
fastest current method.
fastest previous method.
Reseek is based on sequence alignment where each residue in the protein backbone is represented by a
letter in a novel “mega-alphabet” of 85,899,345,920 (∼10<sup>11</sup>) distinct states.
This approach enables rapid construction of multiple alignments of thousands of structures
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