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rcedgar authored Nov 10, 2024
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![Reseek](http://drive5.com/images/reseek_logo.jpg)

Reseek is a protein structure search and alignment algorithm which improves sensitivity in protein homolog detection
compared to state-of-the-art methods including DALI, TM-align and Foldseek with improved speed over Foldseek, the
fastest previous method.
compared to state-of-the-art methods including DALI, TM-align and Foldseek with similar speed to Foldseek.

Reseek is based on sequence alignment where each residue in the protein backbone is represented by a
letter in a novel “mega-alphabet” of 85,899,345,920 (∼10<sup>11</sup>) distinct states.
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