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This is your third homework due Tuesday March 3.

Reproduce the results presented in Figure 2 of the following paper: Qian, F., Bolen, C. R., Jing, C., Wang, X., Zheng, W., Zhao, H., et al. (2013). Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clinical and Vaccine Immunology : CVI, 20(2), 146–155. doi:10.1128/CVI.00530-12

You will have to:

  1. Get the data from GEO
  2. Normalize the data (if necessary)
  3. Use limma to test for differential expression
  4. Display the results using a heatmap [Hint: Use the pheatmap package]