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Merge branch 'main' of https://github.com/pipetcpt/pharmapk
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sueinchoi committed Mar 11, 2024
2 parents 21927ea + 182b471 commit 1092a00
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3 changes: 3 additions & 0 deletions 01.Rmd
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Expand Up @@ -377,6 +377,9 @@ knitr::include_graphics("media-01/image10.png")
결합율이 감소하는 경우(간기능 이상 등으로 혈장단백질 자체가 감소하거나
요독증으로 인해 혈장단백질과 약물의 결합부위를 두고 약물과 경쟁하는 혈중\index{요독증}
노폐물 등의 증가)에는 V~d~가 건강인에 비해 증가함이 알려져 있다.\index{건강인}
물리화학적 특성과 화학 구조가 유사한 같은 계열의 약물들 간에서도 혈장단백질 결합율이 높으면 분포용적이
작은 경향성이 발견된다. 그러나 이런 특수한 상황을 제외하면 일반적으로 혈장단백질 결합율과 분포용적의
상관성은 찾아보기 어렵다.

```{r chart, fig.cap="(ref:chart)", out.width="100%"}
knitr::include_graphics("media-01/chart.png")
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