diff --git a/.github/workflows/python-tests.yml b/.github/workflows/python-tests.yml
new file mode 100644
index 0000000..026b36f
--- /dev/null
+++ b/.github/workflows/python-tests.yml
@@ -0,0 +1,50 @@
+name: Run unit tests
+
+on:
+  pull_request:
+  push:
+    branches:
+    - master
+  workflow_dispatch:
+  schedule:
+    # Run every Sunday at 03:53 UTC
+    - cron: 13 3 * * 0
+
+jobs:
+  tests:
+    name: ${{ matrix.os }}, ${{ matrix.tox_env }}
+    runs-on: ${{ matrix.os }}
+    strategy:
+      matrix:
+        include:
+          - os: ubuntu-latest
+            python-version: '3.7'
+            tox_env: 'py37'
+          - os: ubuntu-latest
+            python-version: '3.8'
+            tox_env: 'py38'
+          - os: ubuntu-latest
+            python-version: '3.9'
+            tox_env: 'py39'
+          - os: ubuntu-latest
+            python-version: '3.10'
+            tox_env: 'py310'
+
+    steps:
+    - uses: actions/checkout@v2
+      with:
+        fetch-depth: 0
+    - name: Set up Python ${{ matrix.python-version }}
+      uses: actions/setup-python@v2
+      with:
+        python-version: ${{ matrix.python-version }}
+    - name: Install Tox
+      run: python -m pip install tox coverage
+    - name: Run Tox
+      run: tox -e ${{ matrix.tox_env }}
+    - name: Convert coverage
+      run: python -m coverage xml
+    - name: Upload coverage to Codecov
+      uses: codecov/codecov-action@v1
+      with:
+        fail_ci_if_error: true
diff --git a/tox.ini b/tox.ini
index 3ea4cb0..15d502f 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,7 @@
 [tox]
 envlist = {py37,py38,py39,py310}{,-mpdafdev},docs
+skip_missing_interpreters = true
+isolated_build = true
 
 [testenv]
 whitelist_externals = which