This repository provides the SimLivA hepatocyte model of ischemia reperfusion injury (IRI) described in
SimLivA – Modelling ischemia reperfusion injury in the liver: A first step towards a clinical decision support tool.
Hans-Michael Tautenhahn, Tim Ricken, Uta Dahmen, Luis Mandl, Laura Bütow, Steffen Gerhäusser, Lena Lambers, Xinpei Chen, Elina Lehmann, Olaf Dirsch, Matthias König
GAMM-Mitteilungen. (2024), e202370003. doi:10.1002/gamm.202370003
The model is distributed as SBML available from iri_liver.xml with
corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/iri-model/main/models/iri_liver.xml
The corresponding perfusion model is available from iri_perfusion.xml with
corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/iri-model/main/models/iri_perfusion.xml
König, Matthias. (2023). Hepatocyte model of ischemia reperfusion injury (IRI).
Zenodo. https://doi.org/10.5281/zenodo.8100310
- Source Code: LGPLv3
- Documentation: CC BY-SA 4.0
- Models: CC BY-SA 4.0
The iri-model source is released under both the GPL and LGPL licenses version 2 or later. You may choose which license you choose to use the software under.
This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License or the GNU Lesser General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 "QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach)" by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2022-2024 Matthias König, Systems Medicine of the Liver