This web application allows the user to explore interactively data from a cohort of 113 myeloproliferative neoplasm (MPN) blood donors and 15 healthy blood controls.
To ensure that the dependencies are fulfilled, you can install the packages needed by running the install_dependencies.R script:
Rscript install_dependencies.R
Represent and compare graphically several variables describing the cohort.
Filter variants to select only the somatic mutations with sufficient evidence. Represent mutated gene per patient and co-occurrence of variants, as well as variants per disease and disease subtypes.
Represent co-occurences of variants and genomic aberrations, occurences of aberrations per disease.
Display summary of genetic events per patient and per disease.
A network, sketching the co-occurences identified for aberrations, mutations and diseases in the other tabs, is also available.
Implement basic cohort description plots
Implement basic variants description plots
Implement full CSS layout
Implement aberration description plots, and patient-wise Circos plots.
Implement disease-wise Circos plots.
Implement co-occurence networks.
- Take into account NAs, non relevant-points and redundancy
- Sort legend on pie charts
- Correct color scheme of one by one matrices
- Complete introduction text