A novel insight into neurological disorders through HDAC6 protein-protein interactions

Extract HDAC6 protein interactions from the literature

The R Client for the Europe PubMed Central RESTful Web Service (europepmc R library) was applied to extract HDAC6 interacting proteins from the selected papers.

Comparison of the literature-based network with a database-driven PPI network

The literature-based network consisting of the retrieved HDAC6 interacting proteins was compared to the database-driven network constructed from the BioGRID and IntAct databases.

Case studies: map expression data of Alzheimer's and Parkinson's disease onto the network

The expression data of Alzheimer's disease (AD) and Parkinson's disease (PD) were mapped onto the literature-based network to visualize AD- and PD-associated changes in the HDAC6 regulatory network.

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