diff --git a/.gitignore b/.gitignore
index c1c92ed..94671ff 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,2 +1,5 @@
 /draft
 /.vscode
+
+# temporal files
+/*/_julia
diff --git a/README.md b/README.md
index bb9ccf6..fe02aa6 100644
--- a/README.md
+++ b/README.md
@@ -2,6 +2,12 @@
 
 Storing different cases for simulation using HetaSimulator (Simulatrix?)
 
+Update heta compiler before run
+
+```julia
+heta_update_dev()
+```
+
 ## List of cases
 
 - **/biochem** : reproduced model from "Biochem J Proteome Res 2014", in LP article.
diff --git a/time-events/index.heta b/time-events/index.heta
new file mode 100644
index 0000000..e979d0e
--- /dev/null
+++ b/time-events/index.heta
@@ -0,0 +1,43 @@
+// === multiple doses ===
+
+comp1 @Compartment .= 1.2;
+s1 @Species {compartment: comp1, isAmount: true} .= 0;
+r1_elim @Reaction {actors: s1=>} := kel1 * s1;
+kel1 @Const = 1e-3;
+dose1 @Const = 100;
+
+dose_sw1 @TimeSwitcher {
+    start: 100,
+    period: 10
+};
+s1 [dose_sw1]= s1 + dose1;
+
+block {output: true} begin
+    comp1; s1;
+end
+
+// === multiple injection ===
+
+comp2 @Compartment .= 1.5;
+s2 @Species {compartment: comp2, isAmount: true} .= 0;
+r2_elim @Reaction {actors: s2=>} := kel2 * s2;
+r3_injection @Reaction {actors: =>s2} := infusion_flag * dose2 / 1; // umole/hour
+kel2 @Const = 1e-4;
+dose2 @Const = 80; // umole
+
+// duration 1 hour
+infusion_on2 @TimeSwitcher {
+    start: 48000,
+    period: 504
+};
+infusion_off2 @TimeSwitcher {
+    start: 48001,
+    period: 504
+};
+infusion_flag @Record .= 0;
+infusion_flag [infusion_on]= 1;
+infusion_flag [infusion_off]= 0;
+
+block {output: true} begin
+    comp2; s2;
+end
diff --git a/time-events/run.jl b/time-events/run.jl
new file mode 100644
index 0000000..a093657
--- /dev/null
+++ b/time-events/run.jl
@@ -0,0 +1,32 @@
+using HetaSimulator, Plots
+
+p = load_platform("./time-events"; rm_out = false);
+model = models(p)[:nameless]
+
+# for s1 : dose
+
+sim(model;
+    tspan = (0, 1200),
+    observables = [:s1]
+) |> plot
+
+sim(model;
+    tspan = (0,1200),
+    observables = [:comp1, :s1],
+    events_on = [:dose_sw1=>false]
+) |> plot
+
+# for s2 : injection
+
+sim(model;
+    tspan = (0, 69_600),
+    #saveat = collect(48000.:720.:69600.),
+    observables = [:comp2, :s2]
+) |> plot
+
+sim(model;
+    span = (0, 69_600),
+    #saveat = collect(48000.:720.:69600.),
+    observables = [:comp2, :s2],
+    events_on = [:infusion_on2=>false, :infusion_off2=>false]
+) |> plot