Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Highlight specific genomic coordinates #102

Open
SarahLampert opened this issue Feb 3, 2025 · 0 comments
Open

Highlight specific genomic coordinates #102

SarahLampert opened this issue Feb 3, 2025 · 0 comments

Comments

@SarahLampert
Copy link

New feature

I’d like to propose adding an option to highlight specific genomic coordinates in the Sashimi plot output.
This feature would allow to emphasize a particular region of interest while still displaying the full splicing landscape of the selected region.

Usage scenario

This feature would be particularly useful when analyzing alternative splicing events that may be driving a phenotype.
Instead of manually searching for specific junctions in different samples, users could specify coordinates or junctions of interest, which would then be highlighted. This would make it easier to compare specific regions between multiple samples and assess whether suspected splicing events are consistent across conditions or phenotypes.

Suggest implementation

The main building blocks of a possible implementation:

  1. New argument for specifying genomic coordinates to highlight. (Could accept a list of multiple regions)

  2. Potential visualization options:

    • Highlighted region on the plot
    • Distinct color for the splice junction arcs corresponding to the coordinates
  3. If multiple samples are plotted, the same region should be highlighted consistently across all plots to facilitate direct comparison.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Development

No branches or pull requests

1 participant