diff --git a/src/platform/packages/shared/kbn-doc-links/src/get_doc_links.ts b/src/platform/packages/shared/kbn-doc-links/src/get_doc_links.ts
index d9d004c56eb59..409b4a61dffff 100644
--- a/src/platform/packages/shared/kbn-doc-links/src/get_doc_links.ts
+++ b/src/platform/packages/shared/kbn-doc-links/src/get_doc_links.ts
@@ -844,7 +844,7 @@ export const getDocLinks = ({ kibanaBranch, buildFlavor }: GetDocLinkOptions): D
       installAndUninstallIntegrationAssets: `${FLEET_DOCS}install-uninstall-integration-assets.html`,
       elasticAgentInputConfiguration: `${FLEET_DOCS}elastic-agent-input-configuration.html`,
       policySecrets: `${FLEET_DOCS}agent-policy.html#agent-policy-secret-values`,
-      remoteESOoutput: `${FLEET_DOCS}monitor-elastic-agent.html#external-elasticsearch-monitoring`,
+      remoteESOoutput: `${FLEET_DOCS}remote-elasticsearch-output.html`,
       performancePresets: `${FLEET_DOCS}es-output-settings.html#es-output-settings-performance-tuning-settings`,
       scalingKubernetesResourcesAndLimits: `${FLEET_DOCS}scaling-on-kubernetes.html#_specifying_resources_and_limits_in_agent_manifests`,
       roleAndPrivileges: `${FLEET_DOCS}fleet-roles-and-privileges.html`,
diff --git a/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/index.test.tsx b/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/index.test.tsx
index 545d28aa58b39..be1abe5948860 100644
--- a/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/index.test.tsx
+++ b/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/index.test.tsx
@@ -350,6 +350,7 @@ describe('EditOutputFlyout', () => {
 
     expect(utils.queryByTestId('serviceTokenSecretInput')).not.toBeNull();
 
+    expect(utils.queryByTestId('remoteClusterConfigurationCallout')).not.toBeNull();
     expect(utils.queryByTestId('kibanaAPIKeyCallout')).not.toBeNull();
     expect(
       (utils.getByTestId('settingsOutputsFlyout.kibanaURLInput') as HTMLInputElement).value
@@ -376,12 +377,21 @@ describe('EditOutputFlyout', () => {
       is_default_monitoring: false,
       service_token: '1234',
       hosts: ['https://localhost:9200'],
+      kibana_url: 'http://localhost:5601',
       kibana_api_key: 'key',
     });
 
     expect((utils.getByTestId('serviceTokenSecretInput') as HTMLInputElement).value).toEqual(
       '1234'
     );
+
+    expect(utils.queryByTestId('settingsOutputsFlyout.kibanaURLInput')).toBeNull();
+    expect(utils.queryByTestId('kibanaAPIKeySecretInput')).toBeNull();
+
+    fireEvent.click(utils.getByTestId('syncIntegrationsSwitch'));
+    expect(
+      (utils.getByTestId('settingsOutputsFlyout.kibanaURLInput') as HTMLInputElement).value
+    ).toEqual('http://localhost:5601');
     expect((utils.getByTestId('kibanaAPIKeySecretInput') as HTMLInputElement).value).toEqual('key');
 
     fireEvent.click(utils.getByText('Save and apply settings'));
@@ -390,9 +400,11 @@ describe('EditOutputFlyout', () => {
       expect(mockSendPutOutput).toHaveBeenCalledWith(
         'outputR',
         expect.objectContaining({
+          sync_integrations: true,
           secrets: { service_token: '1234', kibana_api_key: 'key' },
           service_token: undefined,
           kibana_api_key: undefined,
+          kibana_url: 'http://localhost:5601',
         })
       );
     });
diff --git a/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/output_form_remote_es.tsx b/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/output_form_remote_es.tsx
index 17f7c9ca2abeb..105dc76e591e5 100644
--- a/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/output_form_remote_es.tsx
+++ b/x-pack/platform/plugins/shared/fleet/public/applications/fleet/sections/settings/components/edit_output_flyout/output_form_remote_es.tsx
@@ -13,6 +13,9 @@ import {
   EuiFormRow,
   EuiSpacer,
   EuiSwitch,
+  EuiButton,
+  EuiLink,
+  EuiCode,
 } from '@elastic/eui';
 import { FormattedMessage } from '@kbn/i18n-react';
 import { i18n } from '@kbn/i18n';
@@ -21,6 +24,8 @@ import { MultiRowInput } from '../multi_row_input';
 
 import { ExperimentalFeaturesService } from '../../../../services';
 
+import { useStartServices } from '../../../../hooks';
+
 import type { OutputFormInputsType } from './use_output_form';
 import { SecretFormRow } from './output_form_secret_form_row';
 import { SSLFormSection } from './ssl_form_section';
@@ -38,6 +43,7 @@ export interface IsConvertedToSecret {
 }
 
 export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props) => {
+  const { docLinks } = useStartServices();
   const { inputs, useSecretsStorage, onToggleSecretStorage } = props;
   const [isConvertedToSecret, setIsConvertedToSecret] = React.useState<IsConvertedToSecret>({
     serviceToken: false,
@@ -45,6 +51,8 @@ export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props)
     sslKey: false,
   });
   const { enableSyncIntegrationsOnRemote, enableSSLSecrets } = ExperimentalFeaturesService.get();
+  const [isRemoteClusterInstructionsOpen, setIsRemoteClusterInstructionsOpen] =
+    React.useState(false);
 
   const [isFirstLoad, setIsFirstLoad] = React.useState(true);
 
@@ -192,7 +200,7 @@ export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props)
         title={
           <FormattedMessage
             id="xpack.fleet.settings.editOutputFlyout.serviceTokenCalloutText"
-            defaultMessage="Generate a service token by running this API request in the Remote Kibana Console and copy the response value"
+            defaultMessage="Generate a service token by running this API request in the remote Kibana Console and copy the response value"
           />
         }
         data-test-subj="serviceTokenCallout"
@@ -212,13 +220,14 @@ export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props)
             helpText={
               <FormattedMessage
                 id="xpack.fleet.settings.editOutputFlyout.syncIntegrationsFormRowLabel"
-                defaultMessage="If enabled, Integration assets will be installed on the remote Elasticsearch cluster"
+                defaultMessage="If enabled, integration assets will be installed on the remote Elasticsearch cluster"
               />
             }
             {...inputs.syncIntegrationsInput.formRowProps}
           >
             <EuiSwitch
               {...inputs.syncIntegrationsInput.props}
+              data-test-subj="syncIntegrationsSwitch"
               label={
                 <FormattedMessage
                   id="xpack.fleet.settings.editOutputFlyout.syncIntegrationsSwitchLabel"
@@ -227,91 +236,190 @@ export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props)
               }
             />
           </EuiFormRow>
-          <EuiFormRow
-            fullWidth
-            label={
-              <FormattedMessage
-                id="xpack.fleet.settings.editOutputFlyout.kibanaURLInputLabel"
-                defaultMessage="Remote Kibana URL"
-              />
-            }
-            {...inputs.kibanaURLInput.formRowProps}
-          >
-            <EuiFieldText
-              data-test-subj="settingsOutputsFlyout.kibanaURLInput"
-              fullWidth
-              {...inputs.kibanaURLInput.props}
-              placeholder={i18n.translate(
-                'xpack.fleet.settings.editOutputFlyout.kibanaURLInputPlaceholder',
-                {
-                  defaultMessage: 'Specify Kibana URL',
+          {inputs.syncIntegrationsInput.value === true && (
+            <>
+              <EuiSpacer size="m" />
+              <EuiCallOut
+                iconType="iInCircle"
+                title={
+                  <FormattedMessage
+                    id="xpack.fleet.settings.editOutputFlyout.remoteClusterConfigurationCalloutTitle"
+                    defaultMessage="Additional remote cluster configuration required"
+                  />
                 }
-              )}
-            />
-          </EuiFormRow>
-          <EuiSpacer size="m" />
-          {!useSecretsStorage ? (
-            <SecretFormRow
-              fullWidth
-              label={
-                <FormattedMessage
-                  id="xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyLabel"
-                  defaultMessage="Remote Kibana API Key"
-                />
-              }
-              {...inputs.kibanaAPIKeyInput.formRowProps}
-              useSecretsStorage={useSecretsStorage}
-              onToggleSecretStorage={onToggleSecretAndClearValue}
-            >
-              <EuiFieldText
-                fullWidth
-                data-test-subj="kibanaAPIKeySecretInput"
-                {...inputs.kibanaAPIKeyInput.props}
-                placeholder={i18n.translate(
-                  'xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyPlaceholder',
-                  {
-                    defaultMessage: 'Specify Kibana API Key',
-                  }
+                data-test-subj="remoteClusterConfigurationCallout"
+              >
+                {isRemoteClusterInstructionsOpen ? (
+                  <EuiButton onClick={() => setIsRemoteClusterInstructionsOpen(false)}>
+                    <FormattedMessage
+                      id="xpack.fleet.settings.remoteClusterConfiguration.collapseInstructionsButtonLabel"
+                      defaultMessage="Collapse steps"
+                    />
+                  </EuiButton>
+                ) : (
+                  <EuiButton onClick={() => setIsRemoteClusterInstructionsOpen(true)} fill={true}>
+                    <FormattedMessage
+                      id="xpack.fleet.settings.remoteClusterConfiguration.viewInstructionButtonLabel"
+                      defaultMessage="View steps"
+                    />
+                  </EuiButton>
                 )}
-              />
-            </SecretFormRow>
-          ) : (
-            <SecretFormRow
-              fullWidth
-              title={i18n.translate('xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyLabel', {
-                defaultMessage: 'Remote Kibana API Key',
-              })}
-              {...inputs.kibanaAPIKeySecretInput.formRowProps}
-              cancelEdit={inputs.kibanaAPIKeySecretInput.cancelEdit}
-              useSecretsStorage={useSecretsStorage}
-              isConvertedToSecret={isConvertedToSecret.kibanaAPIKey}
-              onToggleSecretStorage={onToggleSecretAndClearValue}
-            >
-              <EuiFieldText
-                data-test-subj="kibanaAPIKeySecretInput"
+                {isRemoteClusterInstructionsOpen && (
+                  <>
+                    <EuiSpacer size="m" />
+                    <FormattedMessage
+                      id="xpack.fleet.settings.remoteClusterConfiguration.description"
+                      defaultMessage="To sync integrations from this cluster, the remote Elasticsearch output needs additional configuration. {documentationLink}."
+                      values={{
+                        documentationLink: (
+                          <EuiLink external={true} href={docLinks.links.fleet.remoteESOoutput}>
+                            <FormattedMessage
+                              id="xpack.fleet.settings.remoteClusterConfiguration.documentationLink"
+                              defaultMessage="Learn more"
+                            />
+                          </EuiLink>
+                        ),
+                      }}
+                    />
+                    <EuiSpacer size="m" />
+                    <ol>
+                      <li>
+                        <FormattedMessage
+                          id="xpack.fleet.settings.remoteClusterConfiguration.addRemoteClusterStep"
+                          defaultMessage="In the remote cluster, open Kibana and go to {appPath}, and follow the steps to add this cluster."
+                          values={{
+                            appPath: (
+                              <strong>
+                                <FormattedMessage
+                                  id="xpack.fleet.settings.remoteClusterConfiguration.addRemoteClusterKibanaPath"
+                                  defaultMessage="Stack Management > Remote Clusters"
+                                />
+                              </strong>
+                            ),
+                          }}
+                        />
+                        <EuiSpacer size="s" />
+                      </li>
+                      <li>
+                        <FormattedMessage
+                          id="xpack.fleet.settings.remoteClusterConfiguration.replicationStep"
+                          defaultMessage="Go to {appPath} and create a follower index using the cluster from Step 1. The leader index {leaderIndex} from this cluster and should be replicated to the follower index {followerIndex} on the remote cluster."
+                          values={{
+                            appPath: (
+                              <strong>
+                                <FormattedMessage
+                                  id="xpack.fleet.settings.remoteClusterConfiguration.replicationKibanaPath"
+                                  defaultMessage="Stack Management > Cross-Cluster Replication"
+                                />
+                              </strong>
+                            ),
+                            leaderIndex: <EuiCode>fleet-synced-integrations</EuiCode>,
+                            followerIndex: (
+                              <EuiCode>
+                                fleet-synced-integrations-ccr-
+                                {inputs.nameInput.props.value || '<output name>'}
+                              </EuiCode>
+                            ),
+                          }}
+                        />
+                        <EuiSpacer size="s" />
+                      </li>
+                      <li>
+                        <FormattedMessage
+                          id="xpack.fleet.settings.remoteClusterConfiguration.configureKibanaStep"
+                          defaultMessage="Below, provide the access details for the remote cluster's Kibana instance."
+                        />
+                      </li>
+                    </ol>
+                  </>
+                )}
+              </EuiCallOut>
+              <EuiSpacer size="m" />
+              <EuiFormRow
                 fullWidth
-                {...inputs.kibanaAPIKeySecretInput.props}
-                placeholder={i18n.translate(
-                  'xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyPlaceholder',
-                  {
-                    defaultMessage: 'Specify Kibana API Key',
+                label={
+                  <FormattedMessage
+                    id="xpack.fleet.settings.editOutputFlyout.kibanaURLInputLabel"
+                    defaultMessage="Remote Kibana URL"
+                  />
+                }
+                {...inputs.kibanaURLInput.formRowProps}
+              >
+                <EuiFieldText
+                  data-test-subj="settingsOutputsFlyout.kibanaURLInput"
+                  fullWidth
+                  {...inputs.kibanaURLInput.props}
+                  placeholder={i18n.translate(
+                    'xpack.fleet.settings.editOutputFlyout.kibanaURLInputPlaceholder',
+                    {
+                      defaultMessage: 'Specify Kibana URL',
+                    }
+                  )}
+                />
+              </EuiFormRow>
+              <EuiSpacer size="m" />
+              {!useSecretsStorage ? (
+                <SecretFormRow
+                  fullWidth
+                  label={
+                    <FormattedMessage
+                      id="xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyLabel"
+                      defaultMessage="Remote Kibana API Key"
+                    />
                   }
-                )}
-              />
-            </SecretFormRow>
-          )}
-          <EuiSpacer size="m" />
-          <EuiCallOut
-            title={
-              <FormattedMessage
-                id="xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyCalloutText"
-                defaultMessage="Create an API Key by running this API request in the Remote Kibana Console and copy the encoded value"
-              />
-            }
-            data-test-subj="kibanaAPIKeyCallout"
-          >
-            <EuiCodeBlock isCopyable={true}>
-              {` POST /_security/api_key
+                  {...inputs.kibanaAPIKeyInput.formRowProps}
+                  useSecretsStorage={useSecretsStorage}
+                  onToggleSecretStorage={onToggleSecretAndClearValue}
+                >
+                  <EuiFieldText
+                    fullWidth
+                    data-test-subj="kibanaAPIKeySecretInput"
+                    {...inputs.kibanaAPIKeyInput.props}
+                    placeholder={i18n.translate(
+                      'xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyPlaceholder',
+                      {
+                        defaultMessage: 'Specify Kibana API Key',
+                      }
+                    )}
+                  />
+                </SecretFormRow>
+              ) : (
+                <SecretFormRow
+                  fullWidth
+                  title={i18n.translate('xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyLabel', {
+                    defaultMessage: 'Remote Kibana API Key',
+                  })}
+                  {...inputs.kibanaAPIKeySecretInput.formRowProps}
+                  cancelEdit={inputs.kibanaAPIKeySecretInput.cancelEdit}
+                  useSecretsStorage={useSecretsStorage}
+                  isConvertedToSecret={isConvertedToSecret.kibanaAPIKey}
+                  onToggleSecretStorage={onToggleSecretAndClearValue}
+                >
+                  <EuiFieldText
+                    data-test-subj="kibanaAPIKeySecretInput"
+                    fullWidth
+                    {...inputs.kibanaAPIKeySecretInput.props}
+                    placeholder={i18n.translate(
+                      'xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyPlaceholder',
+                      {
+                        defaultMessage: 'Specify Kibana API Key',
+                      }
+                    )}
+                  />
+                </SecretFormRow>
+              )}
+              <EuiSpacer size="m" />
+              <EuiCallOut
+                title={
+                  <FormattedMessage
+                    id="xpack.fleet.settings.editOutputFlyout.kibanaAPIKeyCalloutText"
+                    defaultMessage="Create an API Key by running this API request in the remote Kibana Console and copy the encoded value"
+                  />
+                }
+                data-test-subj="kibanaAPIKeyCallout"
+              >
+                <EuiCodeBlock isCopyable={true}>
+                  {` POST /_security/api_key
    {
      "name": "integration_sync_api_key",
      "role_descriptors": {
@@ -326,9 +434,11 @@ export const OutputFormRemoteEsSection: React.FunctionComponent<Props> = (props)
         }
      }
    }`}
-            </EuiCodeBlock>
-          </EuiCallOut>
-          <EuiSpacer size="m" />
+                </EuiCodeBlock>
+              </EuiCallOut>
+              <EuiSpacer size="m" />
+            </>
+          )}
         </>
       ) : null}
     </>