diff --git a/docker-bsseq/Dockerfile b/docker-bsseq/Dockerfile
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+++ b/docker-bsseq/Dockerfile
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+# Use the Rocker R image
+FROM rocker/r-ver:4.4.0
+
+# Copy installBioc.r script
+RUN cp /usr/local/lib/R/site-library/littler/examples/installBioc.r /usr/local/bin/installBioc.r
+
+# Install BiocManager
+RUN Rscript -e "install.packages('BiocManager')"
+
+# Install system dependencies
+RUN apt-get update && apt-get -y install \
+    less \
+    curl \
+    gzip \
+    lsof \
+    libz-dev \
+    libbz2-dev \
+    liblzma-dev \
+    libxml2 \
+    libxml2-dev \
+    libxt6 \
+    libglpk-dev \
+    libmysqlclient21 \
+    libcurl4-openssl-dev && \
+    python3 \
+    python3-pip && \
+    apt-get clean
+
+# Install Bioconductor packages
+RUN R -e "install.packages('BiocManager'); BiocManager::install(version = '3.19')"
+
+# Install required R and Bioconductor packages
+RUN R -e "install.packages(c('argparse', 'data.table')); \
+    BiocManager::install(c('HDF5Array', 'bsseq', 'DSS', 'GenomicRanges', 'IRanges'))"
+
+# Entry point for the container
+CMD ["bash"]
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