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- identifier: UBERON:0005382
  name: Dorsal Striatum
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- identifier: http://snomed.info/id/11061003
  name: Psychoactive substance use disorder
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acknowledgement: We thank members of the Lerner Laboratory for helpful discussions
  and critical feedback on the manuscript. We thank Gates Palissery, Louis Van Camp,
  Hayden Sikora, and Meghana Holla for assistance with surgeries, histology, and data
  collection and entry. This work was supported by an NIH K99/R00 Award (R00MH109569),
  a NARSAD Young Investigator Award from the Brain & Behavior Research Foundation
  to T.N.L., and an NIH Diversity Supplement (R00MH109569-04S1) to support C.V.C.
  Graphical abstract created with https://biorender.com/.
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  - name: behavioral technique
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    name: Mus musculus - House mouse
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citation: Seiler, Jillian L.; Cosme, Caitlin V.; Sherathiya, Venus N.; Schaid, Michael
  D.; Bianco, Joseph M.; Bridgemohan, Abigael S.; Lerner, Talia N. (2024) Dopamine
  signaling in the dorsomedial striatum promotes compulsive behavior (Version draft)
  [Data set]. DANDI archive. https://dandiarchive.org/dandiset/000971/draft
contributor:
- email: jillian.seiler@northwestern.edu
  identifier: 0000-0003-4430-4797
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  name: Seiler, Jillian L.
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  name: Cosme, Caitlin V.
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- email: venus.sherathiya@northwestern.edu
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  name: Sherathiya, Venus N.
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  name: Schaid, Michael D.
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  name: Bianco, Joseph M.
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  name: Bridgemohan, Abigael S.
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- email: talia.lerner@northwestern.edu
  identifier: 0000-0002-3875-0654
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  name: Lerner, Talia N.
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  name: National Institutes of Health
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  name: National Institutes of Health
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  name: Palissery, Gates
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  name: Van Camp, Louis
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  name: Sikora, Hayden
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  name: Holla, Meghana
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- affiliation: []
  email: paul.wesley.adkisson@gmail.com
  identifier: 0009-0005-8943-5450
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  name: Adkisson, Paul
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dateCreated: '2024-04-27T01:45:05.960750+00:00'
datePublished: '2024-08-02T20:04:03.933450+00:00'
description: "Compulsive behavior is a defining feature of disorders such as substance
  use disorders. Current evidence\nsuggests that corticostriatal circuits control
  the expression of established compulsions, but little is known\nabout the mechanisms
  regulating the development of compulsions. We hypothesized that dopamine, a critical
  modulator of striatal synaptic plasticity, could control alterations in corticostriatal
  circuits leading to the\ndevelopment of compulsions (defined here as continued reward
  seeking in the face of punishment). We used\ndual-site fiber photometry to measure
  dopamine axon activity in the dorsomedial striatum (DMS) and the\ndorsolateral striatum
  (DLS) as compulsions emerged. Individual variability in the speed with which compulsions
  emerged was predicted by DMS dopamine axon activity. Amplifying this dopamine signal
  accelerated\nanimals\u2019 transitions to compulsion, whereas inhibition delayed
  it. In contrast, amplifying DLS dopamine\nsignaling had no effect on the emergence
  of compulsions. These results establish DMS dopamine signaling\nas a key controller
  of the development of compulsive reward seeking."
ethicsApproval: []
id: DANDI:000971/draft
identifier: DANDI:000971
keywords:
- dorsal striatum
- dopamine
- substantia nigra
- reward learning
- habit formation
- compulsive behavior
- punishment-resistant reward seeking
- fiber photometry
- optogenetics
license:
- spdx:CC-BY-4.0
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name: Dopamine signaling in the dorsomedial striatum promotes compulsive behavior
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  name: Dopamine signaling in the dorsomedial striatum promotes compulsive behavior
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  url: https://www.cell.com/current-biology/fulltext/S0960-9822(22)00117-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982222001178%3Fshowall%3Dtrue
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    -- Western Blot Supplement
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