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    name: Neurodata Without Borders (NWB)
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  species:
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citation: Mu, Yu; Bennett, Davis V.; Rubinov, Mikail; Lim, Jing-Xuan; Yang, Chao-Tsung;
  Tanimoto, Masashi; Mensh, Brett D. ; Looger, Loren L.; Narayan, Sujatha; Ahrens,
  Misha B. (2024) Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful
  Behavior (Version 0.240822.1759) [Data set]. DANDI archive. https://doi.org/10.48324/dandi.000350/0.240822.1759
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  email: muy@janelia.hhmi.org
  identifier: 0000-0001-9297-4854
  includeInCitation: true
  name: Mu, Yu
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    name: Janelia Research Campus
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  identifier: 0000-0002-5056-407X
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  name: Bennett, Davis V.
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  name: Rubinov, Mikail
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    name: Howard Hughes Medical Institute
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  name: Lim, Jing-Xuan
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    name: Janelia Research Campus
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  name: Yang, Chao-Tsung
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  - identifier: https://ror.org/013sk6x84
    name: Janelia Research Campus
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  name: Tanimoto, Masashi
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  - identifier: https://ror.org/013sk6x84
    name: Janelia Research Campus
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  name: 'Mensh, Brett D. '
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    name: Janelia Research Campus
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  name: Looger, Loren L.
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    name: Janelia Research Campus
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  name: Narayan, Sujatha
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    name: Janelia Research Campus
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  name: Ahrens, Misha B.
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  url: https://www.janelia.org/lab/ahrens-lab
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  name: Howard Hughes Medical Institute
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  identifier: https://ror.org/01cmst727
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  name: Simons Collaboration on the Global Brain Awards
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    name: CatalystNeuro
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  email: cody.c.baker.phd@gmail.com
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dateCreated: '2022-10-30T19:50:01.557863+00:00'
datePublished: '2024-08-22T17:59:27.040376+00:00'
description: 'When a behavior repeatedly fails to achieve its goal, animals often
  give up and become passive, which can be strategic for preserving energy or regrouping
  between attempts. It is unknown how the brain identifies behavioral failures and
  mediates this behavioral-state switch. In larval zebrafish swimming in virtual reality,
  visual feedback can be withheld so that swim attempts fail to trigger expected visual
  flow. After tens of seconds of such motor futility, animals became passive for similar
  durations. Whole-brain calcium imaging revealed noradrenergic neurons that responded
  specifically to failed swim attempts and radial astrocytes whose calcium levels
  accumulated with increasing numbers of failed attempts. Using cell ablation and
  optogenetic or chemogenetic activation, we found that noradrenergic neurons progressively
  activated brainstem radial astrocytes, which then suppressed swimming. Thus, radial
  astrocytes perform a computation critical for behavior: they accumulate evidence
  that current actions are ineffective and consequently drive changes in behavioral
  states.'
doi: 10.48324/dandi.000350/0.240822.1759
ethicsApproval: []
id: DANDI:000350/0.240822.1759
identifier: DANDI:000350
keywords:
- neuroscience
- glia
- astrocytes
- norepinephrine
- noradrenaline
- learned helplessness
- neuromodulation
- behavioral states
- evidence accumulation
- zebrafish
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://dandiarchive.s3.amazonaws.com/dandisets/000350/0.240822.1759/assets.yaml
name: Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior
protocol: []
publishedBy:
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relatedResource:
- identifier: https://doi.org/10.1016/j.cell.2019.05.050
  name: Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful
    Behavior
  relation: dcite:IsDescribedBy
  repository: Cell
  schemaKey: Resource
  url: https://www.sciencedirect.com/science/article/pii/S009286741930621X
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.3
studyTarget:
- motor activity
- whole-brain
- radial astrocytes
url: https://dandiarchive.org/dandiset/000350/0.240822.1759
version: 0.240822.1759
wasGeneratedBy: []