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metadata.yaml
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about: []
access:
- schemaKey: AccessRequirements
status: dandi:OpenAccess
assetsSummary:
approach:
- name: electrophysiological approach
schemaKey: ApproachType
dataStandard:
- identifier: RRID:SCR_015242
name: Neurodata Without Borders (NWB)
schemaKey: StandardsType
measurementTechnique:
- name: multi electrode extracellular electrophysiology recording technique
schemaKey: MeasurementTechniqueType
- name: surgical technique
schemaKey: MeasurementTechniqueType
- name: analytical technique
schemaKey: MeasurementTechniqueType
- name: signal filtering technique
schemaKey: MeasurementTechniqueType
numberOfBytes: 64243853984
numberOfFiles: 66
numberOfSubjects: 30
schemaKey: AssetsSummary
species:
- identifier: http://purl.obolibrary.org/obo/NCBITaxon_10116
name: Rattus norvegicus - Norway rat
schemaKey: SpeciesType
variableMeasured:
- ProcessingModule
- ElectricalSeries
- LFP
- ElectrodeGroup
citation: Ramachandran, Sandhya; Carnegie Mellon University; Niu, Xiaodan; Yu, Kai;
He, Bin (2024) Local Field Potential Recordings in the Primary Somatosensory Cortex
before and after Transcranial Focused Ultrasound Stimulation in Rats (Version draft)
[Data set]. DANDI archive. https://dandiarchive.org/dandiset/000339/draft
contributor:
- affiliation: []
email: s.ramachandran8@gmail.com
includeInCitation: true
name: Ramachandran, Sandhya
roleName:
- dcite:ContactPerson
schemaKey: Person
- contactPoint: []
identifier: https://ror.org/05x2bcf33
includeInCitation: true
name: Carnegie Mellon University
roleName:
- dcite:Affiliation
schemaKey: Organization
- affiliation:
- identifier: https://ror.org/05x2bcf33
name: Carnegie Mellon University
schemaKey: Affiliation
email: xiaodann@andrew.cmu.edu
includeInCitation: true
name: Niu, Xiaodan
roleName:
- dcite:Author
schemaKey: Person
- affiliation:
- identifier: https://ror.org/05x2bcf33
name: Carnegie Mellon University
schemaKey: Affiliation
email: yukai@cmu.edu
includeInCitation: true
name: Yu, Kai
roleName:
- dcite:Author
schemaKey: Person
- affiliation:
- identifier: https://ror.org/05x2bcf33
name: Carnegie Mellon University
schemaKey: Affiliation
email: bhe1@andrew.cmu.edu
includeInCitation: true
name: He, Bin
roleName:
- dcite:Author
schemaKey: Person
- contactPoint: []
includeInCitation: false
name: NIH MH114233
roleName:
- dcite:Funder
schemaKey: Organization
- contactPoint: []
includeInCitation: false
name: 'NIH NS124564 '
roleName:
- dcite:Funder
schemaKey: Organization
dateCreated: '2022-09-26T20:33:09.788694+00:00'
description: "In this study, we investigate how transcranial focused ultrasound (tFUS)
modulates neural interaction and response to peripheral electrical stimulation at
hindlimb through intracranial multi-electrode recordings in the rat somatosensory
cortex. Recordings were performed using a 32-channel NeuroNexus\xAE multi-electrode
array. Rats were anesthetized using isoflurane at 2%. Recordings were taken while
delivering peripheral electrical stimulation once every 5 seconds to analyze the
neural response in the rat S1HL region, before ultrasound for 30 minutes and then
afterwards for an hour, in order to determine how the ultrasound modulated the electrical
stimulation induced local field potential (LFP) waveforms. We delivered ultrasound
for 5 minutes in a pulsed pattern at 5 levels of sonication repetition frequencies
(SRF) (10 Hz, 50 Hz, 75 Hz, 100 Hz, and 125 Hz) to induce frequency dependent plasticity
in a manner similar to that is found following tetanic electrical stimulation. We
investigated whether delivering tFUS that alters connectivity/correlation between
the targeted neurons may alter collective responses manifested in the modulated
LFP waveforms. The applied fundamental frequency of ultrasound was 0.5 MHz, the
pulse repetition frequency (PRF) was 3 kHz, and the total duty cycle was 36%. This
dataset contains LFP recordings, with 32 channels for each datafile.\nIn each subject,
recordings are provided with \"pre\" and \"post\" tFUS for two different frequencies
(SRF), and most contain recordings during the delivery of ultrasound and during
rest periods between sessions of different ultrasound parameters. For example, a
single subject may include \"100Hz_pre\", \"100Hz_post\", \"50Hz_pre\", \"50Hz_post\",
which are the pre and post tFUS recordings for the two used parameters, and then
\"50Hz\" and \"100Hz\", which are the recordings taken during stimulation, and \"rest1\"
and \"rest2\", which are the rest periods between sessions. These names are preceded
by a label such as \"BH280\", which is the animal subject label. Ultrasound is delivered
in a continuous paradigm, with pulses delivered at the stimulation repetition frequency
continuously throughout the 5 minutes of stimulation. During the \"pre\" and \"post\"
recordings, the peripheral electrical stimulation is delivered once every 5 seconds
approximately. Electrical stimulation event trigger is not included in the dataset
as it was not recorded due to using a separate system to deliver the electrical
stimulation. We were using threshold detection on a channel of LFP recordings in
order to detect the electrical stimulation events, in which events can be recognized
by the quick rising of voltage. One could also approximate it by detecting the first
event, and then add periods of 5 seconds to generate the rest of the trigger times.\nMore
details about the experimental details can be found in our paper published by Journal
of Neural Engineering (DOI: 10.1088/1741-2552/ac889f)."
ethicsApproval: []
id: DANDI:000339/draft
identifier: DANDI:000339
keywords:
- Ultrasound
- tFUS
- Plasticity
- Somatosensory
- Rat
- Somatosensory Cortex
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://api.dandiarchive.org/api/dandisets/000339/versions/draft/assets/
name: Local Field Potential Recordings in the Primary Somatosensory Cortex before
and after Transcranial Focused Ultrasound Stimulation in Rats
protocol: []
relatedResource: []
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.3
studyTarget:
- Somatosensory Cortex
- Rat
- Plasticity
url: https://dandiarchive.org/dandiset/000339/draft
version: draft
wasGeneratedBy: []