metadata.yaml

about:
- identifier: UBERON:0001393
  name: auditory cortex
  schemaKey: Anatomy
access:
- schemaKey: AccessRequirements
  status: dandi:OpenAccess
assetsSummary:
  approach:
  - name: microscopy approach; cell population imaging
    schemaKey: ApproachType
  dataStandard:
  - identifier: RRID:SCR_015242
    name: Neurodata Without Borders (NWB)
    schemaKey: StandardsType
  measurementTechnique:
  - name: surgical technique
    schemaKey: MeasurementTechniqueType
  - name: two-photon microscopy technique
    schemaKey: MeasurementTechniqueType
  numberOfBytes: 97968237237
  numberOfFiles: 777
  numberOfSubjects: 54
  schemaKey: AssetsSummary
  species:
  - identifier: http://purl.obolibrary.org/obo/NCBITaxon_10090
    name: Mus musculus - House mouse
    schemaKey: SpeciesType
  variableMeasured:
  - TwoPhotonSeries
  - OpticalChannel
  - ImagingPlane
citation: Schiavo, Jennifer K.; Valtcheva, Silvana; Bair-Marshall, Chloe J.; Song,
  Soomin C.; Martin, Kathleen A.; Froemke, Robert C. (2024) Innate and plastic mechanisms
  for maternal behaviour in auditory cortex (Version draft) [Data set]. DANDI archive.
  https://dandiarchive.org/dandiset/000249/draft
contributor:
- affiliation: []
  email: ben.dichter@gmail.com
  includeInCitation: false
  name: Dichter, Ben
  roleName: []
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Schiavo, Jennifer K.
  roleName:
  - dcite:Author
  - dcite:ContactPerson
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Valtcheva, Silvana
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Bair-Marshall, Chloe J.
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Song, Soomin C.
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Martin, Kathleen A.
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Froemke, Robert C.
  roleName:
  - dcite:Author
  schemaKey: Person
- awardNumber: 5U19NS107616
  contactPoint: []
  identifier: https://ror.org/01s5ya894
  includeInCitation: false
  name: NINDS
  roleName:
  - dcite:Funder
  schemaKey: Organization
dateCreated: '2022-05-18T13:58:54.819909+00:00'
description: "Infant cries evoke powerful responses in parents. Whether parental animals
  are intrinsically sensitive to neonatal vocalizations, or instead learn about vocal
  cues for parenting responses is unclear. In mice, pup-naive virgin females do not
  recognize the meaning of pup distress calls, but retrieve isolated pups to the nest
  after having been co-housed with a mother and litte. Distress calls are variable,
  and require co-caring virgin mice to generalize across calls for reliable retrieval.
  Here we show that the onset of maternal behaviour in mice results from interactions
  between intrinsic mechanisms and experience-dependent plasticity in the auditory
  cortex. In maternal females, calls with inter-syllable intervals (ISIs) from 75
  to 375 milliseconds elicited pup retrieval, and cortical responses were generalized
  across these ISIs. By contrast, naive virgins were neuronally and behaviourally
  sensitized to the most common (\u2018prototypical\u2019) ISIs. Inhibitory and excitatory
  neural responses were initially mismatched in the cortex of naive mice, with untuned
  inhibition and overly narrow excitation. During co-housing experiments, excitatory
  responses broadened to represent a wider range of ISIs, whereas inhibitory tuning
  sharpened to form a perceptual boundary. We presented synthetic calls during co-housing
  and observed that neurobehavioural responses adjusted to match these statistics,
  a process that required cortical activity and the hypothalamic oxytocin system.
  Neuroplastic mechanisms therefore build on an intrinsic sensitivity in the mouse
  auditory cortex, and enable rapid plasticity for reliable parenting behaviour."
ethicsApproval: []
id: DANDI:000249/draft
identifier: DANDI:000249
keywords:
- oxytocin
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://api.dandiarchive.org/api/dandisets/000249/versions/draft/assets/
name: Innate and plastic mechanisms for maternal behaviour in auditory cortex
protocol: []
relatedResource:
- identifier: https://doi.org/10.1038/s41586-020-2807-6
  name: Innate and plastic mechanisms for maternal behaviour in auditory cortex
  relation: dcite:IsDescribedBy
  repository: Nature
  resourceType: dcite:JournalArticle
  schemaKey: Resource
  url: https://www.nature.com/articles/s41586-020-2807-6
- identifier: https://doi.org/10.6084/m9.figshare.c.5043830.v6
  name: Innate and plastic mechanisms in auditory cortex for maternal behavior
  relation: dcite:IsOriginalFormOf
  repository: FigShare
  resourceType: dcite:Dataset
  schemaKey: Resource
  url: https://figshare.com/collections/Innate_and_plastic_mechanisms_in_auditory_cortex_for_maternal_behavior/5043830
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.3
studyTarget: []
url: https://dandiarchive.org/dandiset/000249/draft
version: draft
wasGeneratedBy: []