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about: []
access:
- schemaKey: AccessRequirements
status: dandi:OpenAccess
assetsSummary:
approach:
- name: microscopy approach; cell population imaging
schemaKey: ApproachType
dataStandard:
- identifier: RRID:SCR_015242
name: Neurodata Without Borders (NWB)
schemaKey: StandardsType
measurementTechnique:
- name: surgical technique
schemaKey: MeasurementTechniqueType
- name: two-photon microscopy technique
schemaKey: MeasurementTechniqueType
numberOfBytes: 97968237237
numberOfFiles: 777
numberOfSubjects: 54
schemaKey: AssetsSummary
species:
- identifier: http://purl.obolibrary.org/obo/NCBITaxon_10090
name: Mus musculus - House mouse
schemaKey: SpeciesType
variableMeasured:
- OpticalChannel
- ImagingPlane
- TwoPhotonSeries
citation: Schiavo, Jennifer K.; Valtcheva, Silvana; Bair-Marshall, Chloe J.; Song,
Soomin C.; Martin, Kathleen A.; Froemke, Robert C. (2023) Innate and plastic mechanisms
for maternal behaviour in auditory cortex (Version 0.230423.1416) [Data set]. DANDI
archive. https://doi.org/10.48324/dandi.000249/0.230423.1416
contributor:
- affiliation: []
email: ben.dichter@gmail.com
includeInCitation: false
name: Dichter, Ben
roleName: []
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Schiavo, Jennifer K.
roleName:
- dcite:Author
- dcite:ContactPerson
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Valtcheva, Silvana
roleName:
- dcite:Author
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Bair-Marshall, Chloe J.
roleName:
- dcite:Author
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Song, Soomin C.
roleName:
- dcite:Author
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Martin, Kathleen A.
roleName:
- dcite:Author
schemaKey: Person
- affiliation: []
includeInCitation: true
name: Froemke, Robert C.
roleName:
- dcite:Author
schemaKey: Person
- awardNumber: 5U19NS107616
contactPoint: []
identifier: https://ror.org/01s5ya894
includeInCitation: false
name: NINDS
roleName:
- dcite:Funder
schemaKey: Organization
dateCreated: '2022-05-18T13:58:54.819909+00:00'
datePublished: '2023-04-23T14:16:50.412829+00:00'
description: "Infant cries evoke powerful responses in parents. Whether parental animals
are intrinsically sensitive to neonatal vocalizations, or instead learn about vocal
cues for parenting responses is unclear. In mice, pup-naive virgin females do not
recognize the meaning of pup distress calls, but retrieve isolated pups to the nest
after having been co-housed with a mother and litte. Distress calls are variable,
and require co-caring virgin mice to generalize across calls for reliable retrieval.
Here we show that the onset of maternal behaviour in mice results from interactions
between intrinsic mechanisms and experience-dependent plasticity in the auditory
cortex. In maternal females, calls with inter-syllable intervals (ISIs) from 75
to 375 milliseconds elicited pup retrieval, and cortical responses were generalized
across these ISIs. By contrast, naive virgins were neuronally and behaviourally
sensitized to the most common (\u2018prototypical\u2019) ISIs. Inhibitory and excitatory
neural responses were initially mismatched in the cortex of naive mice, with untuned
inhibition and overly narrow excitation. During co-housing experiments, excitatory
responses broadened to represent a wider range of ISIs, whereas inhibitory tuning
sharpened to form a perceptual boundary. We presented synthetic calls during co-housing
and observed that neurobehavioural responses adjusted to match these statistics,
a process that required cortical activity and the hypothalamic oxytocin system.
Neuroplastic mechanisms therefore build on an intrinsic sensitivity in the mouse
auditory cortex, and enable rapid plasticity for reliable parenting behaviour."
doi: 10.48324/dandi.000249/0.230423.1416
ethicsApproval: []
id: DANDI:000249/0.230423.1416
identifier: DANDI:000249
keywords:
- oxytocin
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://dandiarchive.s3.amazonaws.com/dandisets/000249/0.230423.1416/assets.yaml
name: Innate and plastic mechanisms for maternal behaviour in auditory cortex
protocol: []
publishedBy:
endDate: '2023-04-23T14:16:50.412829+00:00'
id: urn:uuid:4ba664d9-1114-435e-8321-1371411727ff
name: DANDI publish
schemaKey: PublishActivity
startDate: '2023-04-23T14:16:50.412829+00:00'
wasAssociatedWith:
- id: urn:uuid:e217ce54-8184-4810-b0ea-2b18e85e5cf7
identifier: RRID:SCR_017571
name: DANDI API
schemaKey: Software
version: 0.1.0
relatedResource:
- identifier: https://doi.org/10.1038/s41586-020-2807-6
name: Innate and plastic mechanisms for maternal behaviour in auditory cortex
relation: dcite:IsDescribedBy
repository: Nature
schemaKey: Resource
- identifier: https://doi.org/10.6084/m9.figshare.c.5043830.v6
name: Innate and plastic mechanisms in auditory cortex for maternal behavior
relation: dcite:IsOriginalFormOf
repository: FigShare
schemaKey: Resource
url: https://figshare.com/collections/Innate_and_plastic_mechanisms_in_auditory_cortex_for_maternal_behavior/5043830
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.3
studyTarget: []
url: https://dandiarchive.org/dandiset/000249/0.230423.1416
version: 0.230423.1416
wasGeneratedBy: []