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assetsSummary:
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  - name: electrophysiological approach
    schemaKey: ApproachType
  - name: behavioral approach
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    name: Neurodata Without Borders (NWB)
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  - name: surgical technique
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  - name: multi electrode extracellular electrophysiology recording technique
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  - name: signal filtering technique
    schemaKey: MeasurementTechniqueType
  - name: analytical technique
    schemaKey: MeasurementTechniqueType
  - name: behavioral technique
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  - name: spike sorting technique
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  numberOfSubjects: 18
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    name: Mus musculus - House mouse
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citation: Chang, Yi-Ting; OConnor, Daniel H (2024) Rule-based modulation of a sensorimotor
  transformation across cortical areas (Version draft) [Data set]. DANDI archive.
  https://dandiarchive.org/dandiset/000232/draft
contributor:
- affiliation: []
  email: ychang73@jhmi.edu
  identifier: 0000-0001-5327-250X
  includeInCitation: true
  name: Chang, Yi-Ting
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  schemaKey: Person
- affiliation: []
  email: dan.oconnor@jhmi.edu
  identifier: 0000-0002-9193-6714
  includeInCitation: true
  name: OConnor, Daniel H
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  - dcite:ContactPerson
  schemaKey: Person
- affiliation: []
  email: luiz_tauffer@hotmail.com
  includeInCitation: false
  name: Tauffer, Luiz
  roleName:
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  schemaKey: Person
- affiliation: []
  email: ben.dichter@gmail.com
  identifier: 0000-0001-5725-6910
  includeInCitation: false
  name: Dichter, Ben
  roleName:
  - dcite:Other
  schemaKey: Person
- awardNumber: R01NS089652, 1R01NS104834-01
  contactPoint: []
  identifier: https://ror.org/01cwqze88
  includeInCitation: false
  name: National Institute of Health
  roleName:
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  url: http://www.nih.gov/
- awardNumber: S-2021-GR-045
  contactPoint: []
  identifier: https://ror.org/00kztt736
  includeInCitation: false
  name: The Kavli Foundation
  roleName:
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  url: http://www.kavlifoundation.org/
- contactPoint: []
  includeInCitation: false
  name: Ministry of Education of Taiwan
  roleName:
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  schemaKey: Organization
  url: https://english.moe.gov.tw/mp-1.html
dateCreated: '2022-04-11T15:37:16.661978+00:00'
datePublished: '2024-05-10T20:38:21.534058+00:00'
description: 'Flexible responses to sensory stimuli based on changing rules are critical
  for adapting to a dynamic environment. However, it remains unclear how the brain
  encodes and uses rule information to guide behavior. Here, we made single-unit recordings
  while head-fixed mice performed a cross-modal sensory selection task where they
  switched between two rules: licking in response to tactile stimuli while rejecting
  visual stimuli, or vice versa. Along a cortical sensorimotor processing stream including
  the primary (S1) and secondary (S2) somatosensory areas, and the medial (MM) and
  anterolateral (ALM) motor areas, single-neuron activity distinguished between the
  two rules both prior to and in response to the tactile stimulus. We hypothesized
  that neural populations in these areas would show rule-dependent preparatory states,
  which would shape the subsequent sensory processing and behavior. This hypothesis
  was supported for the motor cortical areas (MM and ALM) by findings that (1) the
  current task rule could be decoded from pre-stimulus population activity; (2) neural
  subspaces containing the population activity differed between the two rules; and
  (3) optogenetic disruption of pre-stimulus states impaired task performance. Our
  findings indicate that flexible action selection in response to sensory input can
  occur via configuration of preparatory states in the motor cortex.'
ethicsApproval: []
id: DANDI:000232/draft
identifier: DANDI:000232
keywords: []
license:
- spdx:CC-BY-4.0
manifestLocation:
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name: Rule-based modulation of a sensorimotor transformation across cortical areas
protocol: []
publishedBy:
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    identifier: RRID:SCR_017571
    name: DANDI API
    schemaKey: Software
    version: 0.1.0
relatedResource:
- identifier: 10.5281/zenodo.11176244
  name: 'Processed data for: Rule-based modulation of a sensorimotor transformation
    across cortical areas'
  relation: dcite:IsSupplementTo
  repository: Zenodo
  resourceType: dcite:Dataset
  schemaKey: Resource
  url: https://zenodo.org/records/11176244
- identifier: 10.1101/2023.08.21.554194
  name: 'Preprint for: Rule-based modulation of a sensorimotor transformation across
    cortical areas'
  relation: dcite:IsSourceOf
  repository: BioRxiv
  resourceType: dcite:Preprint
  schemaKey: Resource
  url: https://www.biorxiv.org/content/10.1101/2023.08.21.554194v2
- identifier: '728394894'
  name: 'Code for: Rule-based modulation of a sensorimotor transformation across cortical
    areas'
  relation: dcite:IsSupplementTo
  repository: GitHub
  resourceType: dcite:Software
  schemaKey: Resource
  url: https://github.com/YitingChang/cross_modal_task.git
- identifier: 12:RP92620
  name: 'Paper for: Rule-based modulation of a sensorimotor transformation across
    cortical areas'
  relation: dcite:IsSourceOf
  repository: eLife
  resourceType: dcite:JournalArticle
  schemaKey: Resource
  url: https://elifesciences.org/reviewed-preprints/92620v1
repository: https://dandiarchive.org
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schemaVersion: 0.6.2
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url: https://dandiarchive.org/dandiset/000232/draft
version: draft
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