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  - name: electrophysiological approach
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  - name: behavioral approach
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  - name: optogenetic approach
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    name: Neurodata Without Borders (NWB)
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  - name: spike sorting technique
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  - name: current clamp technique
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  - name: analytical technique
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citation: Guo, Zengcai; Inagaki, Hidehiko; Daie, Kayvon; Druckmann, Shaul; Gerfen,
  Charles R.; Svoboda, Karel (2024) Maintenance of persistent activity in a frontal
  thalamocortical loop (Version draft) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/000009/draft
contributor:
- identifier: 0000-0002-4140-7961
  includeInCitation: true
  name: Guo, Zengcai
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  - dcite:Author
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- identifier: 0000-0003-4580-2763
  includeInCitation: true
  name: Inagaki, Hidehiko
  roleName:
  - dcite:Author
  schemaKey: Person
- includeInCitation: true
  name: Daie, Kayvon
  roleName:
  - dcite:Author
  schemaKey: Person
- identifier: 0000-0003-0068-3377
  includeInCitation: true
  name: Druckmann, Shaul
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- identifier: 0000-0001-9008-4882
  includeInCitation: true
  name: Gerfen, Charles R.
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- identifier: 0000-0002-6670-7362
  includeInCitation: true
  name: Svoboda, Karel
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dateCreated: '2020-03-18T20:26:50.059000+00:00'
description: We recorded spikes from the ALM and thalamus during tactile discrimination  with
  a delayed directional response. Here we show that, similar to ALM  neurons, thalamic
  neurons exhibited selective persistent delay activity  that predicted movement direction.
  Unilateral photoinhibition of delay  activity in the ALM or thalamus produced contralesional
  neglect.  Photoinhibition of the thalamus caused a short-latency and near-complete  collapse
  of ALM activity. Similarly, photoinhibition of the ALM diminished  thalamic activity.
  Our results show that the thalamus is a circuit hub in  motor preparation and suggest
  that persistent activity requires reciprocal  excitation across multiple brain areas.
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id: DANDI:000009/draft
identifier: DANDI:000009
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license:
- spdx:CC-BY-4.0
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name: Maintenance of persistent activity in a frontal thalamocortical loop
protocol: []
relatedResource:
- identifier: doi:10.1038/nature22324
  name: Maintenance of persistent activity in a frontal thalamocortical loop
  relation: dcite:IsDescribedBy
  repository: Nature
  resourceType: dcite:JournalArticle
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  url: https://doi.org/10.1038/nature22324
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url: https://dandiarchive.org/dandiset/000009/draft
version: draft
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