Structural variants at BRCA1/2 in high grade serous ovarian carcinoma (HGSOC)

This repository is currently in development but will contain the code used for the analysis detailed in the manuscript:

Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

BioRxiv preprint

Contents include:

Commands used for primary processing of the WGS and RNAseq data
Code used to implement the HRDetect model published by Davies et al¹ and instructions for use
Notebooks detailing downstream analysis described in the paper

Contributors

Ailith Ewing

Alison Meynert

Graeme Grimes

^{1. [https://www.nature.com/articles/nm.4292]↩}