Harmonized PGS Questions #404
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TravisMizeIGH
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Hello, I have a few questions about the harmonized PGS:
Can you please define "harmonized" in this context? What steps were taken to harmonize the PGS? Specifically, I am referring to the PGS in your Harmonized directory. Apologies if this is already answered in the documentation, but I am currently unable to find this information.
As part of the harmonization process, are ref/alt SNPs aligned across all PGS? E.g., is it possible that the ref/alt for RS01 is A/G in PGS1 and G/A in PGS2? If the ref/alt alleles are not aligned across PGS, does this create any issues when running batches of multiple PGS?
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