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readme.html
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This is the NEURON code associated with the paper:<p/>
Combe CL, Upchurch CM, Canavier CC, Gasparini S, (2022) Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing <br/>
<p/>
This model entry was contributed by C Canavier. The freely available NEURON
simulation enivronment (from <a href="http://www.neuron.yale.edu">http://www.neuron.yale.edu</a>) is required for this model.<p/>
To use:<br/>
-------<br/>
Autolaunch from modeldb if the browser is capable or compile the mod
files and start with mosinit.hoc (easiest) (If you need more help to run the model,
please refer to:<br/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>)<p/>
On linux for example typing<br/>
nrngui init.hoc
<br/>
Will generate a panels asking what simulation wou want to run.<p/>
<p/>
running one of these simulations will produce a shape plot, a voltage plot, and plots of the calcium concentration in the outermost shell, nanodomain, TRPM4 activation and resulting TRPM4 current in the soma <p/>
<p/>
<p/>
The simulation that reads the original carbachol simulation's calcium and plays it into the model without a voltage dependence cannot be run untill the calcium has been saved. To do this create a folder "nanodomain_data" and run save_can_from_fig9.hoc <p/>
<p/>
Additional running notes:<br/>
-------------------------<br/>
<p/>
Interspike intervals and frequencies were analyzed offline.
<p/>
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