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Copy pathStim20hzACh-sp1.xml
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Stim20hzACh-sp1.xml
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<StimulationSet>
<!-- the injectionSite must match a regionLabel deefined in the morphology -->
<!-- 20 Glu and Ca pulses / sec for 1 sec * 20 trains = 400 pulses -->
<!-- pulse 1 to produce 0.5 uM alone -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 50000 </onset>
<duration> 15 </duration>
<rate> 18 </rate>
<period> 50 </period>
<end> 50020 </end>
</InjectionStim>
<!-- pulse 2 = half of pulse 1 -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 50050 </onset>
<duration> 15 </duration>
<rate> 9.0 </rate>
<period> 50 </period>
<end> 50070 </end>
</InjectionStim>
<!-- pulse 3 = half of pulse 2 -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 50100 </onset>
<duration> 15 </duration>
<rate> 6.3 </rate>
<period> 50 </period>
<end> 50120 </end>
</InjectionStim>
<!-- pulses 4-20 = half of pulse 3, faster injection to decrease stochasticity-->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 50150 </onset>
<duration> 15 </duration>
<rate> 3 </rate>
<period> 50 </period>
<end> 50999 </end>
</InjectionStim>
<!--later bursts of Da - partial strength (2/3d) -->
<!-- pulse 1 to produce 0.5 uM alone -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 60000 </onset>
<duration> 15 </duration>
<rate> 12 </rate>
<period> 50 </period>
<end> 60020 </end>
</InjectionStim>
<!-- pulse 2 = half of pulse 1 -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 60050 </onset>
<duration> 15 </duration>
<rate> 6.0 </rate>
<period> 50 </period>
<end> 60070 </end>
</InjectionStim>
<!-- pulse 3 = half of pulse 2 -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 60100 </onset>
<duration> 15 </duration>
<rate> 4.2 </rate>
<period> 50 </period>
<end> 60120 </end>
</InjectionStim>
<!-- pulses 4-20 = half of pulse 3, faster injection to decrease stochasticity-->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 60150 </onset>
<duration> 15 </duration>
<rate> 2 </rate>
<period> 50 </period>
<end> 60999 </end>
</InjectionStim>
<!--even later bursts of Da - halfstrength -->
<!-- third and subsequent trains even smaller -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 70000 </onset>
<duration> 15 </duration>
<rate> 2.0 </rate>
<period> 50 </period>
<end> 70999 </end>
</InjectionStim>
<!-- fourth and subsequent trains smaller still -->
<InjectionStim specieID="DaDbuf" injectionSite="sa1[0].pointA">
<onset> 80000 </onset>
<duration> 15 </duration>
<rate> 1.0 </rate>
<period> 50 </period>
<end> 80999 </end>
<numTrains> 17 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
<!-- basal ACh value prior to and after stim -->
<InjectionStim specieID="ACh" injectionSite="dend:submembrane">
<onset> 0 </onset>
<duration> 50000 </duration>
<rate> 2 </rate>
</InjectionStim>
<InjectionStim specieID="ACh" injectionSite="dend:submembrane">
<onset> 250000 </onset>
<duration> 200000 </duration>
<rate> 2 </rate>
</InjectionStim>
<!-- basal ACh stim paused during Da stim-->
<InjectionStim specieID="ACh" injectionSite="dend:submembrane">
<onset> 53200 </onset>
<duration> 6800 </duration>
<rate> 2 </rate>
<period> 10000 </period>
<end> 250000 </end>
</InjectionStim>
<!-- burst during stim : Assume that ACh neurons can follow 20 Hz -->
<InjectionStim specieID="ACh" injectionSite="sa1[0].pointA">
<onset> 50000 </onset>
<duration> 15 </duration>
<rate> 3.0 </rate>
<period> 50 </period>
<end> 50999 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
<!-- Should this stimulation be eliminated???-->
<InjectionStim specieID="ACh" injectionSite="dend:submembrane">
<onset> 50000 </onset>
<duration> 15 </duration>
<rate> 30.0 </rate>
<period> 50 </period>
<end> 50999 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
<!-- (no) rebound burst: develops more slowly -->
<InjectionStim specieID="ACh" injectionSite="sa1[0].pointA">
<onset> 52400 </onset>
<duration> 800 </duration>
<rate> 0 </rate>
<period> 900 </period>
<end> 53299 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9101 </interTrainInterval>
</InjectionStim>
<!-- Train 1 -->
<InjectionStim specieID="GluGbuf" injectionSite="sa1[0].pointA">
<onset> 50000 </onset>
<duration> 5 </duration>
<rate> 1.125 </rate>
<period> 50 </period>
<end> 50999 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
<onset> 50000 </onset>
<duration> 3 </duration>
<rate> 156 </rate>
<period> 50 </period>
<end> 50999 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
<InjectionStim specieID="Ca" injectionSite="dend:submembrane">
<onset> 50000 </onset>
<duration> 3 </duration>
<rate> 1560 </rate>
<period> 50 </period>
<end> 50999 </end>
<numTrains> 20 </numTrains>
<interTrainInterval> 9001 </interTrainInterval>
</InjectionStim>
</StimulationSet>