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MSPNreactions_4spine_new.xml
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<ReactionScheme>
<Specie name="Ca" id="Ca" kdiff="174.3" kdiffunit = "mu2/s"/>
<Specie name="CaOut" id="CaOut" kdiff="174.3" kdiffunit = "mu2/s"/>
<Specie name="Calbin" id="Calbin" kdiff="9.3" kdiffunit = "mu2/s"/>
<Specie name="CalbinCa" id="CalbinCa" kdiff="9.3" kdiffunit = "mu2/s"/>
<Specie name="pmca" id="pmca" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="pmcaCa" id="pmcaCa" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ncx" id="ncx" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ncxCa" id="ncxCa" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="LOut" id="LOut" kdiff="150" kdiffunit = "mu2/s"/>
<Specie name="L" id="L" kdiff="150" kdiffunit = "mu2/s"/>
<Specie name="R" id="R" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="G" id="G" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="LRG" id="LRG" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="LR" id="LR" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GR" id="GR" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GaGTP" id="GaGTP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GaGDP" id="GaGDP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="LRGbg" id="LRGbg" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Gbg" id="Gbg" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="AC" id="AC" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ACGaGTP" id="ACGaGTP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ACGaGTPCa" id="ACGaGTPCa" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ATP" id="ATP" kdiff="74.7" kdiffunit = "mu2/s"/>
<Specie name="ACGaGTPCaATP" id="ACGaGTPCaATP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="ACGaGTPATP" id="ACGaGTPATP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="cAMP" id="cAMP" kdiff="86.4" kdiffunit = "mu2/s"/>
<Specie name="ACCa" id="ACCa" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PDE1" id="PDE1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PDE1CamCa4" id="PDE1CamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PDE1CamCa4cAMP" id="PDE1CamCa4cAMP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PDE10" id="PDE10" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PDE10cAMP" id="PDE10cAMP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcPDE10" id="PKAcPDE10" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcPDE10cAMP" id="PKAcPDE10cAMP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcAMP4PDE10" id="PKAcAMP4PDE10" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcAMP4PDE10cAMP" id="PKAcAMP4PDE10cAMP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="pPDE10" id="pPDE10" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="pPDE10cAMP" id="pPDE10cAMP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="AMP" id="AMP" kdiff="85.5" kdiffunit = "mu2/s"/>
<Specie name="CamCa2" id="CamCa2" kdiff="11" kdiffunit = "mu2/s"/>
<Specie name="CamCa4" id="CamCa4" kdiff="11" kdiffunit = "mu2/s"/>
<Specie name="Cam" id="Cam" kdiff="11" kdiffunit = "mu2/s"/>
<Specie name="PP2B" id="PP2B" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2BCam" id="PP2BCam" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2BCamCa2" id="PP2BCamCa2" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2BCamCa4" id="PP2BCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="CK" id="CK" kdiff="3.6" kdiffunit = "mu2/s"/>
<Specie name="CKCamCa4" id="CKCamCa4" kdiff="3.6" kdiffunit = "mu2/s"/>
<Specie name="CKpCamCa4" id="CKpCamCa4" kdiff="3.6" kdiffunit = "mu2/s"/>
<Specie name="CKp" id="CKp" kdiff="3.6" kdiffunit = "mu2/s"/>
<Specie name="Complex" id="Complex" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="pComplex" id="pComplex" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="CKpPP1" id="CKpPP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="CKpCamCa4PP1" id="CKpCamCa4PP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP1" id="PP1" kdiff="0" kdiffunit = "mu2/s"/>
<!-- PKA -->
<Specie name="PKA" id="PKA" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcAMP2" id="PKAcAMP2" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcAMP4" id="PKAcAMP4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="R2C_cAMP4" id="R2C_cAMP4" kdiff="0" kdiffunit= "mu2/s"/>
<Specie name="PKAc" id="PKAc" kdiff="8.1" kdiffunit = "mu2/s"/>
<Specie name="PKAr" id="PKAr" kdiff="0" kdiffunit = "mu2/s"/>
<!-- PP2A -->
<Specie name="PP2A_BPR72" id="PP2A_BPR72" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2A_B56d" id="PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP1PP2BCamCa4" id="PP1PP2BCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<!-- D32,Dp34 -->
<Specie name="D32" id="D32" kdiff="10.6" kdiffunit = "mu2/s"/>
<Specie name="D32PKA" id="D32PKA" kdiff="10.6" kdiffunit = "mu2/s"/>
<Specie name="D32PKAcAMP4" id="D32PKAcAMP4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34" id="Dp34" kdiff="10.6" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP1" id="Dp34PP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP2BCamCa4" id="Dp34PP2BCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP1PP2BCamCa4" id="Dp34PP1PP2BCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP2A_BPR72" id="Dp34PP2A_BPR72" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP2A_B56d" id="Dp34PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP1PP2A_BPR72" id="PP1PP2A_BPR72" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP1PP2A_B56d" id="PP1PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP1PP2A_BPR72" id="Dp34PP1PP2A_BPR72" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp34PP1PP2A_B56d" id="Dp34PP1PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<!-- Dp75 -->
<Specie name="Cdk5" id="Cdk5" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="CDK5D32" id="CDK5D32" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp75" id="Dp75" kdiff="10.6" kdiffunit = "mu2/s"/>
<Specie name="PKAi" id="PKAi" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp75PP2A_BPR72" id="Dp75PP2A_BPR72" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp75PP2A_B56d" id="Dp75PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp75PPaC" id="Dp75PPaC" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="Dp75PPAP" id="Dp75PPAP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcPP2A_B56d" id="PKAcPP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PKAcAMP4PP2A_B56d" id="PKAcAMP4PP2A_B56d" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2AP" id="PP2AP" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="PP2AC" id="PP2AC" kdiff="0" kdiffunit = "mu2/s"/>
<!-- AMPAr -->
<Specie name="GluR1" id="GluR1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845" id="GluR1_S845" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S831" id="GluR1_S831" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_S831" id="GluR1_S845_S831" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_PKAc" id="GluR1_PKAc" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_PKAcAMP4" id="GluR1_PKAcAMP4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S831_PKAc" id="GluR1_S831_PKAc" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S831_PKAcAMP4" id="GluR1_S831_PKAcAMP4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_CKCamCa4" id="GluR1_CKCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_CKpCamCa4" id="GluR1_CKpCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_CKp" id="GluR1_CKp" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_CKCamCa4" id="GluR1_S845_CKCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_CKpCamCa4" id="GluR1_S845_CKpCamCa4" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_CKp" id="GluR1_S845_CKp" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_PP1" id="GluR1_S845_PP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_S831_PP1" id="GluR1_S845_S831_PP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S831_PP1" id="GluR1_S831_PP1" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_PP2B" id="GluR1_S845_PP2B" kdiff="0" kdiffunit = "mu2/s"/>
<Specie name="GluR1_S845_S831_PP2B" id="GluR1_S845_S831_PP2B" kdiff="0" kdiffunit = "mu2/s"/>
<!-- Ca pump high affinity - Ca + pmca <-> pmcaCa -->
<Reaction name = "Ca_pump1a" id="Ca_pump1a">
<Reactant specieID="Ca" />
<Reactant specieID="pmca" />
<Product specieID="pmcaCa" />
<forwardRate> 0.5e-4 </forwardRate>
<reverseRate> 0.007 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Ca pump high affinity - pmcaCa <-> pmca + CaOut -->
<Reaction name = "Ca_pump1b" id="Ca_pump1b">
<Reactant specieID="pmcaCa" />
<Product specieID="pmca" />
<Product specieID="CaOut" />
<forwardRate> 0.0035 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Ca pump low affinity - Ca + ncx <-> ncxCa -->
<Reaction name = "Ca_pump2a" id="Ca_pump2a">
<Reactant specieID="Ca" />
<Reactant specieID="ncx" />
<Product specieID="ncxCa" />
<forwardRate> 1.68e-5 </forwardRate>
<reverseRate> 0.0112 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Ca pump low affinity - ncxCa <-> ncx + CaOut -->
<Reaction name = "Ca_pump2b" id="Ca_pump2b">
<Reactant specieID="ncxCa" />
<Product specieID="ncx" />
<Product specieID="CaOut" />
<forwardRate> 0.0056 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Ca leak - Caout <-> Ca -->
<Reaction name = "Ca_leak" id="Ca_leak">
<Reactant specieID="CaOut" />
<Product specieID="Ca" />
<forwardRate> 1.70e-6 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Ca Buffer Ca + Calbindin <-> CalbinCa -->
<Reaction name = "Ca_buffer" id="Ca_Buffer">
<Reactant specieID="Ca" />
<Reactant specieID="Calbin" />
<Product specieID="CalbinCa" />
<forwardRate> 2.8e-5 </forwardRate>
<reverseRate> 0.0196 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PULSE: Ca -->
<!-- PULSE: L <-> LOut -->
<Reaction name = "L-LOut reac" id="L-LOut_id">
<Reactant specieID="L" />
<Product specieID="LOut" />
<forwardRate> 2.00e-3 </forwardRate>
<reverseRate> 2.00e-8 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- L + R <-> LR (in xpp: k1=0.0011111, k_1=10), Kd=9000 -->
<Reaction name = "L+R--LR reac" id="L+R--LR_id">
<Reactant specieID="L" />
<Reactant specieID="R" />
<Product specieID="LR" />
<forwardRate> 0.0011111e-03 </forwardRate>
<reverseRate> 10e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- LR + G <-> LRG (in xpp: k2=0.0006 k_2=0.001), Kd=1.666667 -->
<Reaction name = "LR+G--LRG reac" id="LR+G--LRG_id">
<Reactant specieID="LR" />
<Reactant specieID="G" />
<Product specieID="LRG" />
<forwardRate> 0.0006e-03 </forwardRate>
<reverseRate> 0.001e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- G + R <-> GR (in xpp: k1a=0.00006 k_1a=0.0003), Kd=5 -->
<Reaction name = "G+R--GR reac" id="G+R--GR_id">
<Reactant specieID="G" />
<Reactant specieID="R" />
<Product specieID="GR" />
<forwardRate> 0.00006e-03 </forwardRate>
<reverseRate> 0.0003e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- GR + L <-> LRG (in xpp: k2a=0.00333333 k_2a=10), Kd=3000 -->
<Reaction name = "GR+L--LRG reac" id="GR+L--LRG_id">
<Reactant specieID="GR" />
<Reactant specieID="L" />
<Product specieID="LRG" />
<forwardRate> 0.0033333e-03 </forwardRate>
<reverseRate> 10e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- The following reaction is incorrect since the
software can't (won't) deal with more than 2
products or reactants
LRG <-> LR + GaGTP + Gbg (in xpp: k3=20), Kd=?
Alternatively, it can be converted in 2 other reactions:
LRG -> LRGbg + GaGTP
LRGbg -> LR + Gbg
-->
<Reaction name = "LRG--LRGbg+GaGTP reac" id="LRG--LRGbg+GaGTP_id">
<Reactant specieID="LRG" />
<Product specieID="LRGbg" />
<Product specieID="GaGTP" />
<forwardRate> 20e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<Reaction name = "LRGbg--LR+Gbg reac" id="LRGbg--LR+Gbg_id">
<Reactant specieID="LRGbg" />
<Product specieID="LR" />
<Product specieID="Gbg" />
<forwardRate> 80e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- GaGTP <-> GaGDP (in xpp: k4=10), Kd=? -->
<Reaction name = "GaGTP--GaGDP reac" id="GaGTP--GaGDP_id">
<Reactant specieID="GaGTP" />
<Product specieID="GaGDP" />
<forwardRate> 10e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- GaGDP + Gbg <-> G (in xpp: k5=100), Kd=? -->
<Reaction name = "GaGDP+Gbg--G reac" id="GaGDP+Gbg--G_id">
<Reactant specieID="GaGDP" />
<Reactant specieID="Gbg" />
<Product specieID="G" />
<forwardRate> 100e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!--
Both (Kf and Kb) have been divided by a 1000 to convert from
sec to msec (xpp->stochdif).
-->
<!-- GaGTP + AC <-> E (in xpp: k6=38461.5e-6 k_6=50)-->
<!-- <forwardRate> 0.0 </forwardRate>
<reverseRate> 0.0 </reverseRate>-->
<Reaction name = "GaGTP+AC--E reac" id="GaGTP+AC--E_AC_id">
<Reactant specieID="GaGTP" />
<Reactant specieID="AC" />
<Product specieID="ACGaGTP" />
<forwardRate> 38461.5e-09 </forwardRate>
<reverseRate> 50e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- ACGaGTP + ATP <-> ACGaGTPATP (in xpp: k7=127600e-9 k_7=0.2612)-->
<Reaction name = "ACGaGTP+ATP--ACGaGTPATP reac" id="ACGaGTP+ATP--ACGaGTPATP_id">
<Reactant specieID="ACGaGTP" />
<Reactant specieID="ATP" />
<Product specieID="ACGaGTPATP" />
<forwardRate> 127600e-12 </forwardRate>
<reverseRate> 0.2612e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- ACGaGTPATP <-> ACGaGTP + CAMP (in xpp: k8=28.46 k_8=259200e-9) -->
<Reaction name = "ACGaGTPATP--ACGaGTP+cAMP reac" id="ACGaGTPATP--ACGaGTP+cAMP_id">
<Reactant specieID="ACGaGTPATP" />
<Product specieID="ACGaGTP" />
<Product specieID="cAMP" />
<forwardRate> 28.46e-03 </forwardRate>
<reverseRate> 259200e-12 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- AC + Ca <-> ACCa (in xpp: k9=0.001 k_9=0.9) -->
<Reaction name = "ACCa reac" id="ACCaid">
<Reactant specieID="AC" />
<Reactant specieID="Ca" />
<Product specieID="ACCa" />
<forwardRate> 0.001e-03 </forwardRate>
<reverseRate> 0.9e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- GaGTP + ACCa <-> ACGaGTPCa (in xpp: k6_2=0.0192308, k_6_2=25) -->
<Reaction name = "ACGaGTPCa reac" id="ACGaGTPCaid">
<Reactant specieID="GaGTP" />
<Reactant specieID="ACCa" />
<Product specieID="ACGaGTPCa" />
<forwardRate> 0.0192308e-03 </forwardRate>
<reverseRate> 25e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- ACGaGTPCa + ATP <-> ACGaGTPCaATP (in xpp: k7_2=0.0000638, k_7_2=0.1306) -->
<Reaction name = "ACGaGTPCaATP reac" id="ACGaGTPCaATPid">
<Reactant specieID="ACGaGTPCa" />
<Reactant specieID="ATP" />
<Product specieID="ACGaGTPCaATP" />
<forwardRate> 0.0000638e-03 </forwardRate>
<reverseRate> 0.1306e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- ACGaGTPCa + ATP <-> cAMP + ACGaGTPCa (in xpp: k8_2=14.23, k_8_2=0.0001296) -->
<Reaction name = "ACGaGTPCa+ATP--cAMP+ACGaGTPCa reac" id="ACGaGTPCa+ATP--cAMP+ACGaGTPCaid">
<Reactant specieID="ACGaGTPCaATP" />
<Product specieID="cAMP" />
<Product specieID="ACGaGTPCa" />
<forwardRate> 14.23e-03 </forwardRate>
<reverseRate> 0.0001296e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PDE1 -->
<!-- PDE1 + CamCa4 <-> PDE1CamCa4 (in xpp: KfpdeCam=0.1, KbpdeCam=1) -->
<Reaction name = "PDE1+CamCa4--PDE1CamCa4" id="PDE1+CamCa4--PDE1CamCa4_id">
<Reactant specieID="PDE1" />
<Reactant specieID="CamCa4" />
<Product specieID="PDE1CamCa4" />
<forwardRate> 0.1e-03 </forwardRate>
<reverseRate> 1.0e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PDE1CamCa4 + cAMP <-> PDE1CamCa4cAMP (in xpp: KfPde1=0.0046 KbPde1=44) -->
<Reaction name = "PDE1CamCa4+cAMP--PDE1CamCa4cAMP" id="PDE1CamCa4+cAMP--PDE1CamCa4cAMP_id">
<Reactant specieID="PDE1CamCa4" />
<Reactant specieID="cAMP" />
<Product specieID="PDE1CamCa4cAMP" />
<forwardRate> 0.0046e-03 </forwardRate>
<reverseRate> 44.0e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PDE1CamCa4cAMP -> PDE1CamCa4 + AMP (in xpp: V_Pde1=11) -->
<Reaction name = "PDE1CamCa4cAMP--PDE1CamCa4+AMP" id="PDE1CamCa4cAMP--PDE1CamCa4+AMP_id">
<Reactant specieID="PDE1CamCa4cAMP" />
<Product specieID="PDE1CamCa4" />
<Product specieID="AMP" />
<forwardRate> 11.00e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PDE10 -->
<!-- PDE10 + cAMP <-> PDE10cAMP (in xpp: KfPDE10= KbPDE10= ) -->
<Reaction name = "PDE10+cAMP--PDE10cAMP" id="PDE10+cAMP--PDE10cAMP_id">
<Reactant specieID="PDE10" />
<Reactant specieID="cAMP" />
<Product specieID="PDE10cAMP" />
<forwardRate> 8.4e-5 </forwardRate>
<reverseRate> 168e-4 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PDE10cAMP -> PDE10 + AMP (in xpp: V_PDE10=18) -->
<Reaction name = "PDE10cAMP--PDE10+AMP" id="PDE10cAMP--PDE10+AMP_id">
<Reactant specieID="PDE10cAMP" />
<Product specieID="PDE10" />
<Product specieID="AMP" />
<forwardRate> 42e-4 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- pPDE10 -->
<!-- PKAc + PDE10 -> PKAcPDE10 -->
<Reaction name = "PDE10 phosp1" id="phospPDE101">
<Reactant specieID="PKAc" />
<Reactant specieID="PDE10" />
<Product specieID="PKAcPDE10" />
<forwardRate> 0.0625e-05 </forwardRate>
<reverseRate> 602.24e-06 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcPDE10 -> PKAc + pPDE10 -->
<Reaction name = "PDE10 phosp2" id="phospPDE102">
<Reactant specieID="PKAcPDE10" />
<Product specieID="pPDE10" />
<Product specieID="PKAc" />
<forwardRate> 150.56e-06 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcAMP4 + PDE10 -> PKAcAMP4PDE10 -->
<Reaction name = "PDE10 phospPDE10PKAcAMP4" id="phospPDE10PKAcAMP4">
<Reactant specieID="PKAcAMP4" />
<Reactant specieID="PDE10" />
<Product specieID="PKAcAMP4PDE10" />
<forwardRate> 0.0625e-06 </forwardRate>
<reverseRate> 602.24e-06 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcAMP4PDE10 -> PKAcPDE10 + R2C_cAMP4 -->
<Reaction name = "PDE10 phospPDE10PKAcAMP4_2" id="phospPDE10PKAcAMP4_2">
<Reactant specieID="PKAcAMP4PDE10" />
<Product specieID="PKAcPDE10" />
<Product specieID="R2C_cAMP4" />
<forwardRate> 0.38e-3 </forwardRate>
<reverseRate> 0.016e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAc + PDE10cAMP -> PKAcPDE10cAMP -->
<Reaction name = "PDE10cAMP phosp1" id="phospPDE10cAMP1">
<Reactant specieID="PKAc" />
<Reactant specieID="PDE10cAMP" />
<Product specieID="PKAcPDE10cAMP" />
<forwardRate> 0.0625e-05 </forwardRate>
<reverseRate> 602.24e-06 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcPDE10cAMP -> PKAc + pPDE10 -->
<Reaction name = "PDE10cAMP phosp2" id="phospPDE10cAMP2">
<Reactant specieID="PKAcPDE10cAMP" />
<Product specieID="pPDE10cAMP" />
<Product specieID="PKAc" />
<forwardRate> 150.56e-06 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcAMP4 + PDE10cAMP -> PKAcAMP4PDE10cAMP -->
<Reaction name = "phospPDE10PKAcAMP4_3" id="phospPDE10PKAcAMP4_3">
<Reactant specieID="PKAcAMP4" />
<Reactant specieID="PDE10cAMP" />
<Product specieID="PKAcAMP4PDE10cAMP" />
<forwardRate> 0.0625e-06 </forwardRate>
<reverseRate> 602.24e-06 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAcAMP4PDE10cAMP -> PKAcPDE10cAMP + R2C_cAMP4 -->
<Reaction name = "phospPDE10PKAcAMP4_4" id="phospPDE10PKAcAMP4_4">
<Reactant specieID="PKAcAMP4PDE10cAMP" />
<Product specieID="PKAcPDE10cAMP" />
<Product specieID="R2C_cAMP4" />
<forwardRate> 0.38e-3 </forwardRate>
<reverseRate> 0.016e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- pPDE10 -> PDE10 -->
<Reaction name = "PDE10 d_phosp" id="dphospPDE10">
<Reactant specieID="pPDE10" />
<Product specieID="PDE10" />
<forwardRate> 10.36e-06 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- pPDE10 + cAMP <-> pPDE10cAMP (in xpp: KfpPDE10= KbpPDE10= ) -->
<Reaction name = "pPDE10+cAMP--pPDE10cAMP" id="pPDE10+cAMP--pPDE10cAMP_id">
<Reactant specieID="pPDE10" />
<Reactant specieID="cAMP" />
<Product specieID="pPDE10cAMP" />
<forwardRate> 10.08e-5 </forwardRate>
<reverseRate> 168e-4 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- pPDE10cAMP -> pPDE10 + AMP (in xpp: V_pPDE10=18) -->
<Reaction name = "pPDE10cAMP--pPDE10+AMP" id="pPDE10cAMP--pPDE10+AMP_id">
<Reactant specieID="pPDE10cAMP" />
<Product specieID="pPDE10" />
<Product specieID="AMP" />
<forwardRate> 84e-4 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- AMP -> ATP (in xpp: katp=10) -->
<Reaction name = "AMP--ATP" id="AMP--ATP_id">
<Reactant specieID="AMP" />
<Product specieID="ATP" />
<forwardRate> 1.00e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!--
Both (Kf and Kb) have been divided by a 1000 to convert from sec to msec
(xpp->stochdif).
-->
<!-- Cam + 2Ca <-> CamCa2 -->
<Reaction name = "Cam+2Ca--CamCa2 reac" id="Cam+2Ca--CamCa2_id">
<Reactant specieID="Cam" />
<Reactant specieID="Ca" n="2" />
<Product specieID="CamCa2" />
<forwardRate> 6.0e-6 </forwardRate>
<reverseRate> 9.1e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CamCa2 + 2Ca <-> CamCa4 -->
<Reaction name = "CamCa2+2Ca--CamCa4 reac" id="CamCa2+2Ca--CamCa4_id">
<Reactant specieID="CamCa2" />
<Reactant specieID="Ca" n="2" />
<Product specieID="CamCa4" />
<forwardRate> 0.1e-03 </forwardRate>
<reverseRate> 1000e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Cam + PP2B <-> PP2BCam (in xpp: k33a=1 k_33a=3) -->
<Reaction name = "Cam+PP2--PP2BCam reac" id="Cam+PP2--PP2BCam_id">
<Reactant specieID="Cam" />
<Reactant specieID="PP2B" />
<Product specieID="PP2BCam" />
<forwardRate> 0.046e-4 </forwardRate>
<reverseRate> 0.0012e-3 </reverseRate>
<!--
<forwardRate> 1e-03 </forwardRate>
<reverseRate> 3e-03 </reverseRate>
-->
<!--
<forwardRate> 1e-05 </forwardRate>
<reverseRate> 3e-05 </reverseRate>
-->
<Q10> 0.2 </Q10>
</Reaction>
<!-- CamCa2 + PP2B <-> PP2BCamCa2 (in xpp: k33c=1 k_33c=0.3) -->
<Reaction name = "CamCa2+PP2--PP2BCamCa2 reac" id="CamCa2+PP2--PP2BCamCa2_id">
<Reactant specieID="CamCa2" />
<Reactant specieID="PP2B" />
<Product specieID="PP2BCamCa2" />
<forwardRate> 0.046e-3 </forwardRate>
<reverseRate> 0.0012e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PP2BCam + Ca2 <-> PP2BCamCa2 -->
<Reaction name = "PP2BCam+Ca2--PP2BCamCa2 reac" id="PP2BCam+Ca2--PP2BCamCa2_id">
<Reactant specieID="PP2BCam" />
<Reactant specieID="Ca" n="2" />
<Product specieID="PP2BCamCa2" />
<forwardRate> 6.0e-06 </forwardRate>
<reverseRate> 0.91e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CamCa4 + PP2B <-> PP2BCamCa4 -->
<Reaction name = "CamCa4+PP2B--PP2BCamCa4 reac" id="CamCa4+PP2B--PP2BCamCa4_id">
<Reactant specieID="CamCa4" />
<Reactant specieID="PP2B" />
<Product specieID="PP2BCamCa4" />
<forwardRate> 0.046e-3 </forwardRate>
<reverseRate> 0.0012e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PP2BCamCa2 + Ca2 <-> PP2BCamCa4 -->
<Reaction name = "PP2BCamCa2+Ca2--PP2BCamCa4 reac" id="PP2BCamCa2+Ca2--PP2BCamCa4_id">
<Reactant specieID="PP2BCamCa2" />
<Reactant specieID="Ca" n="2" />
<Product specieID="PP2BCamCa4" />
<forwardRate> 0.1e-03 </forwardRate>
<reverseRate> 1000e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- New CamKII part -->
<!--1) CamCa4 + CK <-> CKCam -->
<Reaction name = "CK bind" id="CK_bind">
<Reactant specieID="CamCa4" />
<Reactant specieID="CK" />
<Product specieID="CKCamCa4" />
<forwardRate> 0.01e-3 </forwardRate>
<reverseRate> 3e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!--2a) CKCam + CKCam <-> Complex -->
<Reaction name = "CKCam bind" id="CKCam_bind">
<Reactant specieID="CKCamCa4" />
<Reactant specieID="CKCamCa4" />
<Product specieID="Complex" />
<forwardRate> 0.0001e-3 </forwardRate>
<reverseRate> 10e-3 </reverseRate>
<Q10> 2 </Q10>
</Reaction>
<!--2b) CKpCam + CKCam <-> pComplex -->
<Reaction name = "pComplex bind" id="pComplex_bind">
<Reactant specieID="CKpCamCa4" />
<Reactant specieID="CKCamCa4" />
<Product specieID="pComplex" />
<forwardRate> 0.0001e-3 </forwardRate>
<reverseRate> 10e-3 </reverseRate>
<Q10> 2 </Q10>
</Reaction>
<!--3a) CKpCam + Complex <-> CKpCam + pComplex -->
<Reaction name = "CKpCamCompl bind" id="CKpCamCompl_bind">
<Reactant specieID="CKpCamCa4" />
<Reactant specieID="Complex" />
<Product specieID="CKpCamCa4" />
<Product specieID="pComplex" />
<forwardRate> 0.0001e-3 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 2 </Q10>
</Reaction>
<!--3b) CKCam + Complex <-> CKCam + pComplex -->
<Reaction name = "CKCamCompl bind" id="CKCamCompl_bind">
<Reactant specieID="CKCamCa4" />
<Reactant specieID="Complex" />
<Product specieID="CKCamCa4" />
<Product specieID="pComplex" />
<forwardRate> 0.0001e-3 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 2 </Q10>
</Reaction>
<!--4a) Complex + Complex <-> Complex + Pcomplex -->
<Reaction name = "2Complex bind" id="2Complex_bind">
<Reactant specieID="Complex" />
<Reactant specieID="Complex" />
<Product specieID="Complex" />
<Product specieID="pComplex" />
<forwardRate> 0.01e-3 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!--4b) Complex + pComplex <-> Pcomplex + pComplex-->
<Reaction name = "ComplpCompl bind" id="ComplpCompl_bind">
<Reactant specieID="Complex" />
<Reactant specieID="pComplex" />
<Product specieID="pComplex" />
<Product specieID="pComplex" />
<forwardRate> 0.03e-3 </forwardRate>
<reverseRate> 0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CKpCam + CamCa4 <-> CKp -->
<Reaction name = "CKp auto" id="CKp_auto">
<Reactant specieID="CKpCamCa4" />
<Product specieID="CamCa4" />
<Product specieID="CKp" />
<forwardRate> 0.0008e-3 </forwardRate>
<reverseRate> 0.01e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CKp + PP1 <-> CKpPP1 -->
<Reaction name = "CKp bind" id="CKp_bind">
<Reactant specieID="CKp" />
<Reactant specieID="PP1" />
<Product specieID="CKpPP1" />
<forwardRate> 1.0e-08 </forwardRate>
<reverseRate> 0.085e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CKpPP1 -> PP1 + CK -->
<Reaction name = "CKpPP1 reac" id="CKpPP1_reac">
<Reactant specieID="CKpPP1" />
<Product specieID="PP1" />
<Product specieID="CK" />
<forwardRate> 0.025e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CKpCamCa4 + PP1 <-> CKpCamCa4PP1 -->
<Reaction name = "CKpCamCa4PP1_bind" id="CKpCamPP1_bind">
<Reactant specieID="CKpCamCa4" />
<Reactant specieID="PP1" />
<Product specieID="CKpCamCa4PP1" />
<forwardRate> 0.0 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- CKpCamCa4PP1 -> PP1 + CKCamCa4 -->
<Reaction name = "CKpCamCa4PP1_reac" id="CKpCamPP1_reac">
<Reactant specieID="CKpCamCa4PP1" />
<Product specieID="PP1" />
<Product specieID="CKCamCa4" />
<forwardRate> 0.0 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- 2cAMP + PKArc <-> PKAr2cAMP2c2 ( B site binding ) (in xpp: kfhigh=4.3478e-06*3, Kbhigh=0.002*3) -->
<Reaction name = "cAMP B bind" id="cAMP_B_bind">
<Reactant specieID="PKA" />
<Reactant specieID="cAMP" n="2" />
<Product specieID="PKAcAMP2" />
<forwardRate> 8.6956e-8 </forwardRate>
<reverseRate> 0.02e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- 2cAMP + PKAr2cAMP2c2 <-> PKAr2cAMP4c2 ( A site binding ) (in xpp: kfhigh=5.7703e-06*3, Kbhigh=0.02*3) -->
<Reaction name = "cAMP A bind" id="cAMP_A_bind">
<Reactant specieID="PKAcAMP2" />
<Reactant specieID="cAMP" n="2" />
<Product specieID="PKAcAMP4" />
<forwardRate> 11.5406e-8 </forwardRate>
<reverseRate> 0.2e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PKAr2cAMP4c2 <-> PKAr2camp4 + 2PKAc (old PKAc dissociation reaction) -->
<!--
<Reaction name = "PKArc dissocation" id="PKAdissoc">
<Reactant specieID="PKAcAMP4" />
<Product specieID="PKAr" />
<Product specieID="PKAc" n="2" />
<forwardRate> 0.016e-3 </forwardRate>
<reverseRate> 0.0017e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
-->
<!--PKAcAMP4 <-> R2C_cAMP4 + PKAc -->
<Reaction name = "PKAcAMP4_diss2" id="PKAcAMP4_diss2">
<Reactant specieID="PKAcAMP4" />
<Product specieID="R2C_cAMP4" />
<Product specieID="PKAc" />
<forwardRate> 0.038e-3 </forwardRate>
<reverseRate> 0.016e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!--R2C_cAMP4 <-> PKAr + PKAc -->
<Reaction name = "R2C_cAMP_diss" id="R2C_cAMP4_diss">
<Reactant specieID="R2C_cAMP4" />
<Product specieID="PKAr" />
<Product specieID="PKAc" />
<forwardRate> 0.152e-3 </forwardRate>
<reverseRate> 0.004e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- D32 + PKAc <-> D32PKA (in xpp: k20=0.0027 k_20=8 v20=2, Kd=) -->
<Reaction name = "D32+PKAc--D32PKA reac" id="D32+PKAc--D32PKA_id">
<Reactant specieID="D32" />
<Reactant specieID="PKAc" />
<Product specieID="D32PKA" />
<forwardRate> 0.0027e-03 </forwardRate>
<reverseRate> 8.0e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- D32PKA -> PKAc + Dp34 (in xpp: v20=2) -->
<Reaction name = "D32PKA--PKAc+Dp34 reac" id="D32PKA--PKAc+Dp34_id">
<Reactant specieID="D32PKA" />
<Product specieID="PKAc" />
<Product specieID="Dp34" />
<forwardRate> 2.0e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- D32 + PKAcAMP4 <-> D32PKAcAMP4 (in xpp: k20=0.0027 k_20=8 v20=2, Kd=) -->
<Reaction name = "D32+PKAcAMP4--D32PKA reac" id="D32+PKAcAMP4--D32PKA_id">
<Reactant specieID="D32" />
<Reactant specieID="PKAcAMP4" />
<Product specieID="D32PKAcAMP4" />
<forwardRate> 0.0027e-04 </forwardRate>
<reverseRate> 8.0e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- D32PKA -> PKAcAMP4 + Dp34 (in xpp: v20=2) -->
<Reaction name = "D32PKA--PKAcAMP4+Dp34 reac" id="D32PKA--PKAcAMP4+Dp34_id">
<Reactant specieID="D32PKAcAMP4" />
<Product specieID="R2C_cAMP4" />
<Product specieID="D32PKA" />
<forwardRate> 0.38e-3 </forwardRate>
<reverseRate> 0.016e-3 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34 + PP1 <-> Dp34pp1 (in xpp: k21=0.4 k_21=0.58, Kd=) -->
<Reaction name = "Dp34+PP1--Dp34pp1 reac" id="Dp34+PP1--Dp34pp1_id">
<Reactant specieID="Dp34" />
<Reactant specieID="PP1" />
<Product specieID="Dp34PP1" />
<forwardRate> 0.4e-03 </forwardRate>
<reverseRate> 0.58e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34 + PP2BCamCa4 <-> Dp34PP2BCamCa4 (in xpp: k22=0.001 k_22=2, Kd=) -->
<Reaction name = "Dp34+PP2BCamCa4--Dp34PP2BCamCa4 reac" id="Dp34+PP2BCamCa4--Dp34PP2BCamCa4_id">
<Reactant specieID="Dp34" />
<Reactant specieID="PP2BCamCa4" />
<Product specieID="Dp34PP2BCamCa4" />
<forwardRate> 1.785e-07 </forwardRate>
<reverseRate> 2.0e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34PP2BCamCa4 -> D32 + PP2BCamCa4 (in xpp: v22=0.5) -->
<Reaction name = "Dp34PP2BCamCa4--PP2BCamCa4+D32 reac" id="Dp34PP2BCamCa4--PP2BCamCa4+D32_id">
<Reactant specieID="Dp34PP2BCamCa4" />
<Product specieID="PP2BCamCa4" />
<Product specieID="D32" />
<forwardRate> 0.5e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34pp1 + PP2BCamCa4 <-> Dp34PP1PP2BCamCa4 (in xpp: k36=0.001 k_36=2, Kd=) -->
<Reaction name = "Dp34pp1+PP2BCamCa4--Dp34PP1PP2BCamCa4 reac" id="Dp34pp1+PP2BCamCa4--Dp34PP1PP2BCamCa4_id">
<Reactant specieID="Dp34PP1" />
<Reactant specieID="PP2BCamCa4" />
<Product specieID="Dp34PP1PP2BCamCa4" />
<forwardRate> 0.2975e-07 </forwardRate>
<reverseRate> 0.333e-03 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34PP1PP2BCamCa4 -> PP1PP2BCamCa4 + D32 (in xpp: v36=0.5) -->
<Reaction name = "Dp34PP1PP2BCamCa4--PP1PP2BCamCa4+D32 reac" id="Dp34PP1PP2BCamCa4--PP1PP2BCamCa4+D32_id">
<Reactant specieID="Dp34PP1PP2BCamCa4" />
<Product specieID="PP1PP2BCamCa4" />
<Product specieID="D32" />
<forwardRate> 0.0833e-03 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- PP1PP2BCamCa4 -> PP2BCamCa4 + PP1 (in xpp: v36=0.5) -->
<Reaction name = "PP1PP2BCamCa4--PP2BCamCa4+PP1 reac" id="PP1PP2BCamCa4--PP2BCamCa4+PP1_id">
<Reactant specieID="PP1PP2BCamCa4" />
<Product specieID="PP2BCamCa4" />
<Product specieID="PP1" />
<forwardRate> 0.5e-02 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34 + PP2A_BPR72 <-> Dp34PP2A_BPR72 (in xpp: k22b=0.0001 k_22b=2, Kd=) -->
<Reaction name = "Dp34+PP2A_BPR72--Dp34PP2A_BPR72 reac" id="Dp34+PP2A_BPR72--Dp34PP2A_BPR72_id">
<Reactant specieID="Dp34" />
<Reactant specieID="PP2A_BPR72" />
<Product specieID="Dp34PP2A_BPR72" />
<forwardRate> 15.2e-07 </forwardRate>
<reverseRate> 0.056 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34PP2A_BPR72 -> D32 + PP2A_BPR72 (in xpp: v22b=0.5) -->
<Reaction name = "Dp34PP2A_BPR72--PP2A_BPR72+D32 reac" id="Dp34PP2A_BPR72--PP2A_BPR72+D32_id">
<Reactant specieID="Dp34PP2A_BPR72" />
<Product specieID="PP2A_BPR72" />
<Product specieID="D32" />
<forwardRate> 0.014 </forwardRate>
<reverseRate> 0.0 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>
<!-- Dp34 + PP2A_B56d <-> Dp34PP2A_B56d (in xpp: k22b=0.0001 k_22b=2, Kd=) -->
<Reaction name = "Dp34+PP2A_B56d--Dp34PP2A_B56d reac" id="Dp34+PP2A_B56d--Dp34PP2A_B56d_id">
<Reactant specieID="Dp34" />
<Reactant specieID="PP2A_B56d" />
<Product specieID="Dp34PP2A_B56d" />
<forwardRate> 15.2e-07 </forwardRate>
<reverseRate> 0.056 </reverseRate>
<Q10> 0.2 </Q10>
</Reaction>