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KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
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This is the readme for the model associated with the paper: Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol 591:1771-91 This model was contributed by Dr Volker Steuber. The computer code was written in NEURON which is freely available at http://www.neuron.yale.edu Use: auto-launch from ModelDB or download, extract, and compile the mod files with the "nrnivmodl" command after cd'ing to the extracted folder (linux/unix), or drag and drop the folder on the mknrndll icon (Mac OS X), or cd'ing to the folder with mknrndll (mswin). Start the simulation by pressing return a couple times (during autolaunch to compile and start), drag and drop one of the below files on the nrngui icon (Mac OS X), or double clicking one of the below files (mswin). The following scripts replicate figures in Ovsepian et al. (2013) Fig 9A,B: DCN_spontact_loop_main.hoc Fig 9C,D: DCN_rebound_main.hoc Fig 9E: DCN_cip_fi_main.hoc Fig 9F: DCN_cip_axis_main.hoc They each produce the appropriate data files and then exit. Note that DCN_cip_axis_main.hoc takes just a few minutes so if you want a quick demo try that instead of the longer scripts. Changelog ========= * 20220924: Update MOD files to avoid declaring variables and functions with the same name. See neuronsimulator/nrn#1992
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KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
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