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CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
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NEURON mod files from the paper: Mala M. Shah, Michele Migliore, and David A. Brown, Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. J Physiol. 2011 589:6029-38. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy. The fig-3c.hoc reproduces the traces shown in Fig.3c of the paper. Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui fig-3c.hoc Under Windows systems: to compile the mod files use the "mknrndll" command. A double click on the simulation file fig-3c.hoc will open the simulation window. Questions on how to use this model should be directed to michele.migliore@cnr.it
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CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)
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