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Copy pathGPcomps_newGP.g
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GPcomps_newGP.g
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//FILE IN USE 09/30/2004 -- present.
//genesis - genesis2.2 script, J Hanson 5/02
//axon rebuilt with hillock, initial segment, nodes and internodal
// segments 06/25/2004 according to Shen et al (1999).
// 06/28/2004: added KCNQ to axon, added G_mult_KCNQ_dend and G_mult_KCNQ_axon
// 09/30/2004: changed dendritic subclassifications to match the data of
// Hanson & Smith, 2004.
float PI = 3.14159
function make_GP_comps
float len, dia, surf, rad, vol, core_vol, shell_vol
float rad_core, shell_vol
int i
/* make spherical soma prototype */
len = 0
dia = 1
rad = {dia}/2.0
rad_core = rad - {shell_thick}
surf = 4*{PI}*rad*rad
vol = 4/3*{PI}*rad*rad*rad
core_vol = 4/3*{PI}*rad_core*rad_core*rad_core
shell_vol = vol - core_vol
if (!({exists GP_soma}))
create compartment GP_soma
end
setfield GP_soma Cm {{CM}*surf} Ra {8.0*{RA}/({dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
/* put channels in soma */
copy Ca_HVA_GP GP_soma/Ca_HVA_GP_somahill
addmsg GP_soma GP_soma/Ca_HVA_GP_somahill VOLTAGE Vm
addmsg GP_soma/Ca_HVA_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Ca_HVA_GP_somahill Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_soma}*{G_mult}}
copy K_ahp_GP GP_soma/K_ahp_GP_somahill
addmsg GP_soma GP_soma/K_ahp_GP_somahill VOLTAGE Vm
addmsg GP_soma/K_ahp_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/K_ahp_GP_somahill Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_soma}*{G_mult}}
copy Ca_GP_nernst GP_soma/Ca_GP_nernst
copy Ca_GP_conc GP_soma/Ca_GP_conc
addmsg GP_soma/Ca_HVA_GP_somahill GP_soma/Ca_GP_conc I_Ca Ik
addmsg GP_soma/Ca_GP_conc GP_soma/Ca_HVA_GP_somahill CONCEN Ca
addmsg GP_soma/Ca_GP_conc GP_soma/K_ahp_GP_somahill CONCEN Ca
addmsg GP_soma/Ca_GP_conc GP_soma/Ca_GP_nernst CIN Ca
addmsg GP_soma/Ca_GP_nernst GP_soma/Ca_HVA_GP_somahill EK E
setfield GP_soma/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_soma/Na_fast_GP_somahill
addmsg GP_soma GP_soma/Na_fast_GP_somahill VOLTAGE Vm
addmsg GP_soma/Na_fast_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Na_fast_GP_somahill Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_soma}*{G_mult}}
copy Na_slow_GP GP_soma/Na_slow_GP_somahill
addmsg GP_soma GP_soma/Na_slow_GP_somahill VOLTAGE Vm
addmsg GP_soma/Na_slow_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Na_slow_GP_somahill Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_soma}*{G_mult}}
copy Kv3_GP GP_soma/Kv3_GP_somahill
addmsg GP_soma GP_soma/Kv3_GP_somahill VOLTAGE Vm
addmsg GP_soma/Kv3_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Kv3_GP_somahill Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_soma}*{G_mult}}
copy Kv2_GP GP_soma/Kv2_GP_somahill
addmsg GP_soma GP_soma/Kv2_GP_somahill VOLTAGE Vm
addmsg GP_soma/Kv2_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Kv2_GP_somahill Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_soma}*{G_mult}}
copy Kv4_fast_GP GP_soma/Kv4_fast_GP_somahill
addmsg GP_soma GP_soma/Kv4_fast_GP_somahill VOLTAGE Vm
addmsg GP_soma/Kv4_fast_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Kv4_fast_GP_somahill Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_soma}*{G_mult}}
copy Kv4_slow_GP GP_soma/Kv4_slow_GP_somahill
addmsg GP_soma GP_soma/Kv4_slow_GP_somahill VOLTAGE Vm
addmsg GP_soma/Kv4_slow_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/Kv4_slow_GP_somahill Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_soma}*{G_mult}}
copy KCNQ_GP GP_soma/KCNQ_GP_somahill
addmsg GP_soma GP_soma/KCNQ_GP_somahill VOLTAGE Vm
addmsg GP_soma/KCNQ_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/KCNQ_GP_somahill Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_soma}*{G_mult}}
copy h_HCN_GP GP_soma/h_HCN_GP_somahill
addmsg GP_soma GP_soma/h_HCN_GP_somahill VOLTAGE Vm
addmsg GP_soma/h_HCN_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/h_HCN_GP_somahill Gbar \
{{G_h_HCN_GP}*surf*{G_mult}}
copy h_HCN2_GP GP_soma/h_HCN2_GP_somahill
addmsg GP_soma GP_soma/h_HCN2_GP_somahill VOLTAGE Vm
addmsg GP_soma/h_HCN2_GP_somahill GP_soma CHANNEL Gk Ek
setfield GP_soma/h_HCN2_GP_somahill Gbar \
{{G_h_HCN2_GP}*surf*{G_mult}}
/* make axon hillock prototype --> extension of soma */
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2.0})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_axHill}))
create compartment GP_axHill
end
setfield GP_axHill Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
/* put channels in axon hillock --> same as soma */
copy Ca_HVA_GP GP_axHill/Ca_HVA_GP_somahill
addmsg GP_axHill GP_axHill/Ca_HVA_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Ca_HVA_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Ca_HVA_GP_somahill Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_soma}*{G_mult}}
copy K_ahp_GP GP_axHill/K_ahp_GP_somahill
addmsg GP_axHill GP_axHill/K_ahp_GP_somahill VOLTAGE Vm
addmsg GP_axHill/K_ahp_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/K_ahp_GP_somahill Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_soma}*{G_mult}}
copy Ca_GP_nernst GP_axHill/Ca_GP_nernst
copy Ca_GP_conc GP_axHill/Ca_GP_conc
addmsg GP_axHill/Ca_HVA_GP_somahill GP_axHill/Ca_GP_conc I_Ca Ik
addmsg GP_axHill/Ca_GP_conc GP_axHill/Ca_HVA_GP_somahill CONCEN Ca
addmsg GP_axHill/Ca_GP_conc GP_axHill/K_ahp_GP_somahill CONCEN Ca
addmsg GP_axHill/Ca_GP_conc GP_axHill/Ca_GP_nernst CIN Ca
addmsg GP_axHill/Ca_GP_nernst GP_axHill/Ca_HVA_GP_somahill EK E
setfield GP_axHill/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_axHill/Na_fast_GP_somahill
addmsg GP_axHill GP_axHill/Na_fast_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Na_fast_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Na_fast_GP_somahill Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_soma}*{G_mult}}
copy Na_slow_GP GP_axHill/Na_slow_GP_somahill
addmsg GP_axHill GP_axHill/Na_slow_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Na_slow_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Na_slow_GP_somahill Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_soma}*{G_mult}}
copy Kv3_GP GP_axHill/Kv3_GP_somahill
addmsg GP_axHill GP_axHill/Kv3_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Kv3_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Kv3_GP_somahill Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_soma}*{G_mult}}
copy Kv2_GP GP_axHill/Kv2_GP_somahill
addmsg GP_axHill GP_axHill/Kv2_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Kv2_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Kv2_GP_somahill Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_soma}*{G_mult}}
copy Kv4_fast_GP GP_axHill/Kv4_fast_GP_somahill
addmsg GP_axHill GP_axHill/Kv4_fast_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Kv4_fast_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Kv4_fast_GP_somahill Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_soma}*{G_mult}}
copy Kv4_slow_GP GP_axHill/Kv4_slow_GP_somahill
addmsg GP_axHill GP_axHill/Kv4_slow_GP_somahill VOLTAGE Vm
addmsg GP_axHill/Kv4_slow_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/Kv4_slow_GP_somahill Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_soma}*{G_mult}}
copy KCNQ_GP GP_axHill/KCNQ_GP_somahill
addmsg GP_axHill GP_axHill/KCNQ_GP_somahill VOLTAGE Vm
addmsg GP_axHill/KCNQ_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/KCNQ_GP_somahill Gbar \
{{G_KCNQ_GP}*surf*{G_mult}}
copy h_HCN_GP GP_axHill/h_HCN_GP_somahill
addmsg GP_axHill GP_axHill/h_HCN_GP_somahill VOLTAGE Vm
addmsg GP_axHill/h_HCN_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/h_HCN_GP_somahill Gbar \
{{G_h_HCN_GP}*surf*{G_mult}}
copy h_HCN2_GP GP_axHill/h_HCN2_GP_somahill
addmsg GP_axHill GP_axHill/h_HCN2_GP_somahill VOLTAGE Vm
addmsg GP_axHill/h_HCN2_GP_somahill GP_axHill CHANNEL Gk Ek
setfield GP_axHill/h_HCN2_GP_somahill Gbar \
{{G_h_HCN2_GP}*surf*{G_mult}}
/* make axon initial segment prototype--> low Rm */
len = 1
dia = 1
rad = {dia} / 2
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (!({exists GP_axIS}))
create compartment GP_axIS
end
setfield GP_axIS Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_ax} initVm {EREST_ACT} Rm {{RM_ax}/surf} inject 0.0 \
dia {dia} len {len}
/* put channels in axon initial segment */
copy Na_fast_GP GP_axIS/Na_fast_GP_IS
addmsg GP_axIS GP_axIS/Na_fast_GP_IS VOLTAGE Vm
addmsg GP_axIS/Na_fast_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Na_fast_GP_IS Gbar \
{{G_Na_fast_GP}*surf*{G_mult_Na_IS}*{G_mult}}
copy Na_slow_GP GP_axIS/Na_slow_GP_IS
addmsg GP_axIS GP_axIS/Na_slow_GP_IS VOLTAGE Vm
addmsg GP_axIS/Na_slow_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Na_slow_GP_IS Gbar \
{{G_Na_slow_GP}*surf*{G_mult_Na_IS}*{G_mult}}
copy Kv4_fast_GP GP_axIS/Kv4_fast_GP_IS
addmsg GP_axIS GP_axIS/Kv4_fast_GP_IS VOLTAGE Vm
addmsg GP_axIS/Kv4_fast_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Kv4_fast_GP_IS Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_axon}*{G_mult}}
copy Kv4_slow_GP GP_axIS/Kv4_slow_GP_IS
addmsg GP_axIS GP_axIS/Kv4_slow_GP_IS VOLTAGE Vm
addmsg GP_axIS/Kv4_slow_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Kv4_slow_GP_IS Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_axon}*{G_mult}}
copy Kv3_GP GP_axIS/Kv3_GP_IS
addmsg GP_axIS GP_axIS/Kv3_GP_IS VOLTAGE Vm
addmsg GP_axIS/Kv3_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Kv3_GP_IS Gbar \
{{G_Kv3_GP}*surf*{G_mult_Kdr_IS}*{G_mult}}
copy Kv2_GP GP_axIS/Kv2_GP_IS
addmsg GP_axIS GP_axIS/Kv2_GP_IS VOLTAGE Vm
addmsg GP_axIS/Kv2_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/Kv2_GP_IS Gbar \
{{G_Kv2_GP}*surf*{G_mult_Kdr_IS}*{G_mult}}
copy KCNQ_GP GP_axIS/KCNQ_GP_IS
addmsg GP_axIS GP_axIS/KCNQ_GP_IS VOLTAGE Vm
addmsg GP_axIS/KCNQ_GP_IS GP_axIS CHANNEL Gk Ek
setfield GP_axIS/KCNQ_GP_IS Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_axon}*{G_mult}}
/* make axon internodal segment prototype--> low Cm, high Rm, no chans */
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (!({exists GP_axIN}))
create compartment GP_axIN
end
setfield GP_axIN Cm {{CM_my}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_ax} initVm {EREST_ACT} Rm {{RM_my}/surf} inject 0.0 \
dia {dia} len {len}
// no channels in axIN segments.
/* make axon node prototype--> same characteristics as initial segment */
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (!({exists GP_axNode}))
create compartment GP_axNode
end
setfield GP_axNode Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_ax} initVm {EREST_ACT} Rm {{RM_ax}/surf} inject 0.0 \
dia {dia} len {len}
/* put channels in node--> exclude NaP to prevent spontaneous initiation */
copy Na_fast_GP GP_axNode/Na_fast_GP_node
addmsg GP_axNode GP_axNode/Na_fast_GP_node VOLTAGE Vm
addmsg GP_axNode/Na_fast_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Na_fast_GP_node Gbar \
{{G_Na_fast_GP}*surf*{G_mult_Na_axon}*{G_mult}}
/*
copy Na_slow_GP GP_axNode/Na_slow_GP_node
addmsg GP_axNode GP_axNode/Na_slow_GP_node VOLTAGE Vm
addmsg GP_axNode/Na_slow_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Na_slow_GP_node Gbar \
{{G_Na_slow_GP}*surf*{G_mult_Na_axon}*{G_mult}}
*/
copy Kv4_fast_GP GP_axNode/Kv4_fast_GP_node
addmsg GP_axNode GP_axNode/Kv4_fast_GP_node VOLTAGE Vm
addmsg GP_axNode/Kv4_fast_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Kv4_fast_GP_node Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_axon}*{G_mult}}
copy Kv4_slow_GP GP_axNode/Kv4_slow_GP_node
addmsg GP_axNode GP_axNode/Kv4_slow_GP_node VOLTAGE Vm
addmsg GP_axNode/Kv4_slow_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Kv4_slow_GP_node Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_axon}*{G_mult}}
copy Kv3_GP GP_axNode/Kv3_GP_node
addmsg GP_axNode GP_axNode/Kv3_GP_node VOLTAGE Vm
addmsg GP_axNode/Kv3_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Kv3_GP_node Gbar \
{{G_Kv3_GP}*surf*{G_mult_Kdr_axon}*{G_mult}}
copy Kv2_GP GP_axNode/Kv2_GP_node
addmsg GP_axNode GP_axNode/Kv2_GP_node VOLTAGE Vm
addmsg GP_axNode/Kv2_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/Kv2_GP_node Gbar \
{{G_Kv2_GP}*surf*{G_mult_Kdr_axon}*{G_mult}}
copy KCNQ_GP GP_axNode/KCNQ_GP_node
addmsg GP_axNode GP_axNode/KCNQ_GP_node VOLTAGE Vm
addmsg GP_axNode/KCNQ_GP_node GP_axNode CHANNEL Gk Ek
setfield GP_axNode/KCNQ_GP_node Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_axon}*{G_mult}}
// Dendritic prototype = dendrite_p
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dendrite_p}))
create compartment GP_dendrite_p
end
setfield GP_dendrite_p Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dendrite
copy Ca_HVA_GP GP_dendrite_p/Ca_HVA_GP
addmsg GP_dendrite_p GP_dendrite_p/Ca_HVA_GP VOLTAGE Vm
addmsg GP_dendrite_p/Ca_HVA_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Ca_HVA_GP Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dendrite_p/K_ahp_GP
addmsg GP_dendrite_p GP_dendrite_p/K_ahp_GP VOLTAGE Vm
addmsg GP_dendrite_p/K_ahp_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/K_ahp_GP Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dendrite_p/Ca_GP_nernst
copy Ca_GP_conc GP_dendrite_p/Ca_GP_conc
addmsg GP_dendrite_p/Ca_HVA_GP GP_dendrite_p/Ca_GP_conc I_Ca Ik
addmsg GP_dendrite_p/Ca_GP_conc GP_dendrite_p/Ca_HVA_GP CONCEN Ca
addmsg GP_dendrite_p/Ca_GP_conc GP_dendrite_p/K_ahp_GP CONCEN Ca
addmsg GP_dendrite_p/Ca_GP_conc GP_dendrite_p/Ca_GP_nernst CIN Ca
addmsg GP_dendrite_p/Ca_GP_nernst GP_dendrite_p/Ca_HVA_GP EK E
setfield GP_dendrite_p/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dendrite_p/Na_fast_GP
addmsg GP_dendrite_p GP_dendrite_p/Na_fast_GP VOLTAGE Vm
addmsg GP_dendrite_p/Na_fast_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Na_fast_GP Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dendrite_p/Na_slow_GP
addmsg GP_dendrite_p GP_dendrite_p/Na_slow_GP VOLTAGE Vm
addmsg GP_dendrite_p/Na_slow_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Na_slow_GP Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}
copy Kv3_GP GP_dendrite_p/Kv3_GP
addmsg GP_dendrite_p GP_dendrite_p/Kv3_GP VOLTAGE Vm
addmsg GP_dendrite_p/Kv3_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Kv3_GP Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_dend}*{G_mult}}
copy Kv2_GP GP_dendrite_p/Kv2_GP
addmsg GP_dendrite_p GP_dendrite_p/Kv2_GP VOLTAGE Vm
addmsg GP_dendrite_p/Kv2_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Kv2_GP Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_dend}*{G_mult}}
copy Kv4_fast_GP GP_dendrite_p/Kv4_fast_GP
addmsg GP_dendrite_p GP_dendrite_p/Kv4_fast_GP VOLTAGE Vm
addmsg GP_dendrite_p/Kv4_fast_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Kv4_fast_GP Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_dend}*{G_mult}}
copy Kv4_slow_GP GP_dendrite_p/Kv4_slow_GP
addmsg GP_dendrite_p GP_dendrite_p/Kv4_slow_GP VOLTAGE Vm
addmsg GP_dendrite_p/Kv4_slow_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/Kv4_slow_GP Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_dend}*{G_mult}}
copy KCNQ_GP GP_dendrite_p/KCNQ_GP
addmsg GP_dendrite_p GP_dendrite_p/KCNQ_GP VOLTAGE Vm
addmsg GP_dendrite_p/KCNQ_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/KCNQ_GP Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_dend}*{G_mult}}
copy h_HCN_GP GP_dendrite_p/h_HCN_GP
addmsg GP_dendrite_p GP_dendrite_p/h_HCN_GP VOLTAGE Vm
addmsg GP_dendrite_p/h_HCN_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/h_HCN_GP Gbar \
{{G_h_HCN_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
copy h_HCN2_GP GP_dendrite_p/h_HCN2_GP
addmsg GP_dendrite_p GP_dendrite_p/h_HCN2_GP VOLTAGE Vm
addmsg GP_dendrite_p/h_HCN2_GP GP_dendrite_p CHANNEL Gk Ek
setfield GP_dendrite_p/h_HCN2_GP Gbar \
{{G_h_HCN2_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
// Dendritic prototype = dendrite_dend3_distal25compts (dia0)
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dend3_distal25compts}))
create compartment GP_dend3_distal25compts
end
setfield GP_dend3_distal25compts Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dend3_distal25compts dendrite
copy Ca_HVA_GP GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dend3_distal25compts/Ca_GP_nernst
copy Ca_GP_conc GP_dend3_distal25compts/Ca_GP_conc
addmsg GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts GP_dend3_distal25compts/Ca_GP_conc I_Ca Ik
addmsg GP_dend3_distal25compts/Ca_GP_conc GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts CONCEN Ca
addmsg GP_dend3_distal25compts/Ca_GP_conc GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts CONCEN Ca
addmsg GP_dend3_distal25compts/Ca_GP_conc GP_dend3_distal25compts/Ca_GP_nernst CIN Ca
addmsg GP_dend3_distal25compts/Ca_GP_nernst GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts EK E
setfield GP_dend3_distal25compts/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dend3_distal25compts/Na_fast_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Na_fast_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Na_fast_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Na_fast_GP_dend3_distal25compts Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dend3_distal25compts/Na_slow_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Na_slow_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Na_slow_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Na_slow_GP_dend3_distal25compts Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}
copy Kv3_GP GP_dend3_distal25compts/Kv3_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Kv3_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Kv3_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Kv3_GP_dend3_distal25compts Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_dend}*{G_mult}}
copy Kv2_GP GP_dend3_distal25compts/Kv2_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Kv2_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Kv2_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Kv2_GP_dend3_distal25compts Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_dend}*{G_mult}}
copy Kv4_fast_GP GP_dend3_distal25compts/Kv4_fast_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Kv4_fast_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Kv4_fast_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Kv4_fast_GP_dend3_distal25compts Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_distal_KV4F_mult}}
copy Kv4_slow_GP GP_dend3_distal25compts/Kv4_slow_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/Kv4_slow_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/Kv4_slow_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/Kv4_slow_GP_dend3_distal25compts Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_distal_KV4S_mult}}
copy KCNQ_GP GP_dend3_distal25compts/KCNQ_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/KCNQ_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/KCNQ_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/KCNQ_GP_dend3_distal25compts Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_dend}*{G_mult}}
copy h_HCN_GP GP_dend3_distal25compts/h_HCN_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/h_HCN_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/h_HCN_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/h_HCN_GP_dend3_distal25compts Gbar \
{{G_h_HCN_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
copy h_HCN2_GP GP_dend3_distal25compts/h_HCN2_GP_dend3_distal25compts
addmsg GP_dend3_distal25compts GP_dend3_distal25compts/h_HCN2_GP_dend3_distal25compts VOLTAGE Vm
addmsg GP_dend3_distal25compts/h_HCN2_GP_dend3_distal25compts GP_dend3_distal25compts CHANNEL Gk Ek
setfield GP_dend3_distal25compts/h_HCN2_GP_dend3_distal25compts Gbar \
{{G_h_HCN2_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
// for the distal 25 compts, diameter specification is unnecessary bc all are dia0
// scaling HVA:
setfield GP_dend3_distal25compts/Ca_HVA_GP_dend3_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*3.0*{dend3_distal_HVA_mult}}
// scaling SK:
setfield GP_dend3_distal25compts/K_ahp_GP_dend3_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_distal_SK_mult}}
// Dendritic prototype = dendrite_dend3_mid25compts (dia0)
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dend3_mid25compts}))
create compartment GP_dend3_mid25compts
end
setfield GP_dend3_mid25compts Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dend3_mid25compts dendrite
copy Ca_HVA_GP GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dend3_mid25compts/Ca_GP_nernst
copy Ca_GP_conc GP_dend3_mid25compts/Ca_GP_conc
addmsg GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts GP_dend3_mid25compts/Ca_GP_conc I_Ca Ik
addmsg GP_dend3_mid25compts/Ca_GP_conc GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts CONCEN Ca
addmsg GP_dend3_mid25compts/Ca_GP_conc GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts CONCEN Ca
addmsg GP_dend3_mid25compts/Ca_GP_conc GP_dend3_mid25compts/Ca_GP_nernst CIN Ca
addmsg GP_dend3_mid25compts/Ca_GP_nernst GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts EK E
setfield GP_dend3_mid25compts/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dend3_mid25compts/Na_fast_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Na_fast_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Na_fast_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Na_fast_GP_dend3_mid25compts Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dend3_mid25compts/Na_slow_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Na_slow_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Na_slow_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Na_slow_GP_dend3_mid25compts Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}
copy Kv3_GP GP_dend3_mid25compts/Kv3_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Kv3_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Kv3_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Kv3_GP_dend3_mid25compts Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_dend}*{G_mult}}
copy Kv2_GP GP_dend3_mid25compts/Kv2_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Kv2_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Kv2_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Kv2_GP_dend3_mid25compts Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_dend}*{G_mult}}
copy Kv4_fast_GP GP_dend3_mid25compts/Kv4_fast_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Kv4_fast_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Kv4_fast_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Kv4_fast_GP_dend3_mid25compts Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_mid_KV4F_mult}}
copy Kv4_slow_GP GP_dend3_mid25compts/Kv4_slow_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/Kv4_slow_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/Kv4_slow_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/Kv4_slow_GP_dend3_mid25compts Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_mid_KV4S_mult}}
copy KCNQ_GP GP_dend3_mid25compts/KCNQ_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/KCNQ_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/KCNQ_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/KCNQ_GP_dend3_mid25compts Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_dend}*{G_mult}}
copy h_HCN_GP GP_dend3_mid25compts/h_HCN_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/h_HCN_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/h_HCN_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/h_HCN_GP_dend3_mid25compts Gbar \
{{G_h_HCN_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
copy h_HCN2_GP GP_dend3_mid25compts/h_HCN2_GP_dend3_mid25compts
addmsg GP_dend3_mid25compts GP_dend3_mid25compts/h_HCN2_GP_dend3_mid25compts VOLTAGE Vm
addmsg GP_dend3_mid25compts/h_HCN2_GP_dend3_mid25compts GP_dend3_mid25compts CHANNEL Gk Ek
setfield GP_dend3_mid25compts/h_HCN2_GP_dend3_mid25compts Gbar \
{{G_h_HCN2_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
// make compartment prototypes for different diameters of mid dend3 compartments
if (!({exists GP_dend3_mid25compts_dia1}))
copy GP_dend3_mid25compts GP_dend3_mid25compts_dia1
end
if (!({exists GP_dend3_mid25compts_dia2}))
copy GP_dend3_mid25compts GP_dend3_mid25compts_dia2
end
// scale HVA for mid dend3 compartments
setfield GP_dend3_mid25compts/Ca_HVA_GP_dend3_mid25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*3*{dend3_mid_HVA_mult}}
setfield GP_dend3_mid25compts_dia1/Ca_HVA_GP_dend3_mid25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*1.5*{dend3_mid_HVA_mult}}
setfield GP_dend3_mid25compts_dia2/Ca_HVA_GP_dend3_mid25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*{dend3_mid_HVA_mult}}
// scaling SK:
setfield GP_dend3_mid25compts/K_ahp_GP_dend3_mid25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_mid_SK_mult}}
setfield GP_dend3_mid25compts_dia1/K_ahp_GP_dend3_mid25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_mid_SK_mult}}
setfield GP_dend3_mid25compts_dia2/K_ahp_GP_dend3_mid25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_mid_SK_mult}}
// Dendritic prototype = dendrite_dend3_proximal25compts (dia0)
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dend3_proximal25compts}))
create compartment GP_dend3_proximal25compts
end
setfield GP_dend3_proximal25compts Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dend3_proximal25compts dendrite
copy Ca_HVA_GP GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dend3_proximal25compts/Ca_GP_nernst
copy Ca_GP_conc GP_dend3_proximal25compts/Ca_GP_conc
addmsg GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts GP_dend3_proximal25compts/Ca_GP_conc I_Ca Ik
addmsg GP_dend3_proximal25compts/Ca_GP_conc GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts CONCEN Ca
addmsg GP_dend3_proximal25compts/Ca_GP_conc GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts CONCEN Ca
addmsg GP_dend3_proximal25compts/Ca_GP_conc GP_dend3_proximal25compts/Ca_GP_nernst CIN Ca
addmsg GP_dend3_proximal25compts/Ca_GP_nernst GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts EK E
setfield GP_dend3_proximal25compts/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dend3_proximal25compts/Na_fast_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Na_fast_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Na_fast_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Na_fast_GP_dend3_proximal25compts Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dend3_proximal25compts/Na_slow_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Na_slow_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Na_slow_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Na_slow_GP_dend3_proximal25compts Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}
copy Kv3_GP GP_dend3_proximal25compts/Kv3_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Kv3_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Kv3_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Kv3_GP_dend3_proximal25compts Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_dend}*{G_mult}}
copy Kv2_GP GP_dend3_proximal25compts/Kv2_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Kv2_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Kv2_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Kv2_GP_dend3_proximal25compts Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_dend}*{G_mult}}
copy Kv4_fast_GP GP_dend3_proximal25compts/Kv4_fast_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Kv4_fast_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Kv4_fast_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Kv4_fast_GP_dend3_proximal25compts Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_proximal_KV4F_mult}}
copy Kv4_slow_GP GP_dend3_proximal25compts/Kv4_slow_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/Kv4_slow_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/Kv4_slow_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/Kv4_slow_GP_dend3_proximal25compts Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend3_proximal_KV4S_mult}}
copy KCNQ_GP GP_dend3_proximal25compts/KCNQ_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/KCNQ_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/KCNQ_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/KCNQ_GP_dend3_proximal25compts Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_dend}*{G_mult}}
copy h_HCN_GP GP_dend3_proximal25compts/h_HCN_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/h_HCN_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/h_HCN_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/h_HCN_GP_dend3_proximal25compts Gbar \
{{G_h_HCN_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
copy h_HCN2_GP GP_dend3_proximal25compts/h_HCN2_GP_dend3_proximal25compts
addmsg GP_dend3_proximal25compts GP_dend3_proximal25compts/h_HCN2_GP_dend3_proximal25compts VOLTAGE Vm
addmsg GP_dend3_proximal25compts/h_HCN2_GP_dend3_proximal25compts GP_dend3_proximal25compts CHANNEL Gk Ek
setfield GP_dend3_proximal25compts/h_HCN2_GP_dend3_proximal25compts Gbar \
{{G_h_HCN2_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
// make compartment prototypes for different diameters of mid dend3 compartments
if (!({exists GP_dend3_proximal25compts_dia1}))
copy GP_dend3_proximal25compts GP_dend3_proximal25compts_dia1
end
if (!({exists GP_dend3_proximal25compts_dia2}))
copy GP_dend3_proximal25compts GP_dend3_proximal25compts_dia2
end
// scale HVA for proximal dend3 compartments
setfield GP_dend3_proximal25compts/Ca_HVA_GP_dend3_proximal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*3*{dend3_proximal_HVA_mult}}
setfield GP_dend3_proximal25compts_dia1/Ca_HVA_GP_dend3_proximal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*1.5*{dend3_proximal_HVA_mult}}
setfield GP_dend3_proximal25compts_dia2/Ca_HVA_GP_dend3_proximal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*{dend3_proximal_HVA_mult}}
// scaling SK:
setfield GP_dend3_proximal25compts/K_ahp_GP_dend3_proximal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_proximal_SK_mult}}
setfield GP_dend3_proximal25compts_dia1/K_ahp_GP_dend3_proximal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_proximal_SK_mult}}
setfield GP_dend3_proximal25compts_dia2/K_ahp_GP_dend3_proximal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend3_proximal_SK_mult}}
// Dendritic prototype = dendrite_dend2_distal25compts (dia0)
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dend2_distal25compts}))
create compartment GP_dend2_distal25compts
end
setfield GP_dend2_distal25compts Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dend2_distal25compts dendrite
copy Ca_HVA_GP GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dend2_distal25compts/Ca_GP_nernst
copy Ca_GP_conc GP_dend2_distal25compts/Ca_GP_conc
addmsg GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts GP_dend2_distal25compts/Ca_GP_conc I_Ca Ik
addmsg GP_dend2_distal25compts/Ca_GP_conc GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts CONCEN Ca
addmsg GP_dend2_distal25compts/Ca_GP_conc GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts CONCEN Ca
addmsg GP_dend2_distal25compts/Ca_GP_conc GP_dend2_distal25compts/Ca_GP_nernst CIN Ca
addmsg GP_dend2_distal25compts/Ca_GP_nernst GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts EK E
setfield GP_dend2_distal25compts/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dend2_distal25compts/Na_fast_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Na_fast_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Na_fast_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Na_fast_GP_dend2_distal25compts Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dend2_distal25compts/Na_slow_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Na_slow_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Na_slow_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Na_slow_GP_dend2_distal25compts Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}
copy Kv3_GP GP_dend2_distal25compts/Kv3_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Kv3_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Kv3_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Kv3_GP_dend2_distal25compts Gbar \
{{G_Kv3_GP}*surf*{G_mult_KV3_dend}*{G_mult}}
copy Kv2_GP GP_dend2_distal25compts/Kv2_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Kv2_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Kv2_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Kv2_GP_dend2_distal25compts Gbar \
{{G_Kv2_GP}*surf*{G_mult_KV2_dend}*{G_mult}}
copy Kv4_fast_GP GP_dend2_distal25compts/Kv4_fast_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Kv4_fast_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Kv4_fast_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Kv4_fast_GP_dend2_distal25compts Gbar \
{{G_Kv4_fast_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend2_distal_KV4F_mult}}
copy Kv4_slow_GP GP_dend2_distal25compts/Kv4_slow_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/Kv4_slow_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/Kv4_slow_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/Kv4_slow_GP_dend2_distal25compts Gbar \
{{G_Kv4_slow_GP}*surf*{G_mult_KA_dend}*{G_mult}*{dend2_distal_KV4S_mult}}
copy KCNQ_GP GP_dend2_distal25compts/KCNQ_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/KCNQ_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/KCNQ_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/KCNQ_GP_dend2_distal25compts Gbar \
{{G_KCNQ_GP}*surf*{G_mult_KCNQ_dend}*{G_mult}}
copy h_HCN_GP GP_dend2_distal25compts/h_HCN_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/h_HCN_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/h_HCN_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/h_HCN_GP_dend2_distal25compts Gbar \
{{G_h_HCN_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
copy h_HCN2_GP GP_dend2_distal25compts/h_HCN2_GP_dend2_distal25compts
addmsg GP_dend2_distal25compts GP_dend2_distal25compts/h_HCN2_GP_dend2_distal25compts VOLTAGE Vm
addmsg GP_dend2_distal25compts/h_HCN2_GP_dend2_distal25compts GP_dend2_distal25compts CHANNEL Gk Ek
setfield GP_dend2_distal25compts/h_HCN2_GP_dend2_distal25compts Gbar \
{{G_h_HCN2_GP}*surf*{G_mult_HCN_dend}*{G_mult}}
// make compartment prototypes for different diameters of distal dend2 compartments
if (!({exists GP_dend2_distal25compts_dia1}))
copy GP_dend2_distal25compts GP_dend2_distal25compts_dia1
end
if (!({exists GP_dend2_distal25compts_dia2}))
copy GP_dend2_distal25compts GP_dend2_distal25compts_dia2
end
// scale HVA for distal dend2 compartments
setfield GP_dend2_distal25compts/Ca_HVA_GP_dend2_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*3*{dend2_distal_HVA_mult}}
setfield GP_dend2_distal25compts_dia1/Ca_HVA_GP_dend2_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*1.5*{dend2_distal_HVA_mult}}
setfield GP_dend2_distal25compts_dia2/Ca_HVA_GP_dend2_distal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}*{dend2_distal_HVA_mult}}
// scaling SK:
setfield GP_dend2_distal25compts/K_ahp_GP_dend2_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend2_distal_SK_mult}}
setfield GP_dend2_distal25compts_dia1/K_ahp_GP_dend2_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend2_distal_SK_mult}}
setfield GP_dend2_distal25compts_dia2/K_ahp_GP_dend2_distal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}*{dend2_distal_SK_mult}}
// Dendritic prototype = dendrite_dend2_proximal25compts (dia0)
len = 1
dia = 1
rad = {dia} / 2.0
surf = 2*{PI}*rad*{len}
vol = {PI}*rad*rad*{len}
if (dia > {{shell_thick}*2})
rad_core = rad - {shell_thick}
core_vol = {PI}*rad_core*rad_core*{len}
shell_vol = vol - core_vol
else
shell_vol = vol
end
if (!({exists GP_dend2_proximal25compts}))
create compartment GP_dend2_proximal25compts
end
setfield GP_dend2_proximal25compts Cm {{CM}*surf} Ra {4.0*{RA}*{len}/({dia}*{dia}*{PI})} \
Em {ELEAK_sd} initVm {EREST_ACT} Rm {{RM_sd}/surf} inject 0.0 \
dia {dia} len {len}
// Put shared channels in prototype dend2_proximal25compts dendrite
copy Ca_HVA_GP GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts
addmsg GP_dend2_proximal25compts GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts VOLTAGE Vm
addmsg GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts GP_dend2_proximal25compts CHANNEL Gk Ek
setfield GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts Gbar \
{{G_Ca_HVA_GP}*surf*{G_mult_Ca_dend}*{G_mult}}
copy K_ahp_GP GP_dend2_proximal25compts/K_ahp_GP_dend2_proximal25compts
addmsg GP_dend2_proximal25compts GP_dend2_proximal25compts/K_ahp_GP_dend2_proximal25compts VOLTAGE Vm
addmsg GP_dend2_proximal25compts/K_ahp_GP_dend2_proximal25compts GP_dend2_proximal25compts CHANNEL Gk Ek
setfield GP_dend2_proximal25compts/K_ahp_GP_dend2_proximal25compts Gbar \
{{G_K_ahp_GP}*surf*{G_mult_SK_dend}*{G_mult}}
copy Ca_GP_nernst GP_dend2_proximal25compts/Ca_GP_nernst
copy Ca_GP_conc GP_dend2_proximal25compts/Ca_GP_conc
addmsg GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts GP_dend2_proximal25compts/Ca_GP_conc I_Ca Ik
addmsg GP_dend2_proximal25compts/Ca_GP_conc GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts CONCEN Ca
addmsg GP_dend2_proximal25compts/Ca_GP_conc GP_dend2_proximal25compts/K_ahp_GP_dend2_proximal25compts CONCEN Ca
addmsg GP_dend2_proximal25compts/Ca_GP_conc GP_dend2_proximal25compts/Ca_GP_nernst CIN Ca
addmsg GP_dend2_proximal25compts/Ca_GP_nernst GP_dend2_proximal25compts/Ca_HVA_GP_dend2_proximal25compts EK E
setfield GP_dend2_proximal25compts/Ca_GP_conc B {{B_Ca_GP_conc}/shell_vol}
copy Na_fast_GP GP_dend2_proximal25compts/Na_fast_GP_dend2_proximal25compts
addmsg GP_dend2_proximal25compts GP_dend2_proximal25compts/Na_fast_GP_dend2_proximal25compts VOLTAGE Vm
addmsg GP_dend2_proximal25compts/Na_fast_GP_dend2_proximal25compts GP_dend2_proximal25compts CHANNEL Gk Ek
setfield GP_dend2_proximal25compts/Na_fast_GP_dend2_proximal25compts Gbar \
{{G_Na_fast_GP}*surf*{G_mult_NaF_dend}*{G_mult}}
copy Na_slow_GP GP_dend2_proximal25compts/Na_slow_GP_dend2_proximal25compts
addmsg GP_dend2_proximal25compts GP_dend2_proximal25compts/Na_slow_GP_dend2_proximal25compts VOLTAGE Vm
addmsg GP_dend2_proximal25compts/Na_slow_GP_dend2_proximal25compts GP_dend2_proximal25compts CHANNEL Gk Ek
setfield GP_dend2_proximal25compts/Na_slow_GP_dend2_proximal25compts Gbar \
{{G_Na_slow_GP}*surf*{G_mult_NaS_dend}*{G_mult}}