diff --git a/charts/datadog/CHANGELOG.md b/charts/datadog/CHANGELOG.md
index 2574fccc4..3da3aac32 100644
--- a/charts/datadog/CHANGELOG.md
+++ b/charts/datadog/CHANGELOG.md
@@ -1,5 +1,9 @@
 # Datadog changelog
 
+## 3.106.0
+
+* Target based workload selection for Single Step Instrumentation has been added in preview (requires Cluster Agent 7.64.0+)
+
 ## 3.105.0
 
 * Add `datadog.discovery.networkStats.enabled` configuration to control Service Discovery network stats collection.
diff --git a/charts/datadog/Chart.yaml b/charts/datadog/Chart.yaml
index 8b7c0a81a..26f1d0255 100644
--- a/charts/datadog/Chart.yaml
+++ b/charts/datadog/Chart.yaml
@@ -1,7 +1,7 @@
 ---
 apiVersion: v1
 name: datadog
-version: 3.105.0
+version: 3.106.0
 appVersion: "7"
 description: Datadog Agent
 keywords:
diff --git a/charts/datadog/README.md b/charts/datadog/README.md
index c44914e7e..b7c979c3c 100644
--- a/charts/datadog/README.md
+++ b/charts/datadog/README.md
@@ -1,6 +1,6 @@
 # Datadog
 
-![Version: 3.105.0](https://img.shields.io/badge/Version-3.105.0-informational?style=flat-square) ![AppVersion: 7](https://img.shields.io/badge/AppVersion-7-informational?style=flat-square)
+![Version: 3.106.0](https://img.shields.io/badge/Version-3.106.0-informational?style=flat-square) ![AppVersion: 7](https://img.shields.io/badge/AppVersion-7-informational?style=flat-square)
 
 [Datadog](https://www.datadoghq.com/) is a hosted infrastructure monitoring platform. This chart adds the Datadog Agent to all nodes in your cluster via a DaemonSet. It also optionally depends on the [kube-state-metrics chart](https://github.com/prometheus-community/helm-charts/tree/main/charts/kube-state-metrics). For more information about monitoring Kubernetes with Datadog, please refer to the [Datadog documentation website](https://docs.datadoghq.com/agent/basic_agent_usage/kubernetes/).
 
@@ -703,6 +703,7 @@ helm install <RELEASE_NAME> \
 | datadog.apm.instrumentation.language_detection.enabled | bool | `true` | Run language detection to automatically detect languages of user workloads (preview). |
 | datadog.apm.instrumentation.libVersions | object | `{}` | Inject specific version of tracing libraries with Single Step Instrumentation (preview). |
 | datadog.apm.instrumentation.skipKPITelemetry | bool | `false` | Disable generating Configmap for APM Instrumentation KPIs |
+| datadog.apm.instrumentation.targets | list | `[]` | Enable target based workload selection (preview). Requires Cluster Agent 7.64.0+ |
 | datadog.apm.port | int | `8126` | Override the trace Agent port |
 | datadog.apm.portEnabled | bool | `false` | Enable APM over TCP communication (hostPort 8126 by default) |
 | datadog.apm.socketEnabled | bool | `true` | Enable APM over Socket (Unix Socket or windows named pipe) |
diff --git a/charts/datadog/ci/apm-single-step-instrumentation-admission-controller-values.yaml b/charts/datadog/ci/apm-single-step-instrumentation-admission-controller-values.yaml
index e16325d78..63d36fa8b 100644
--- a/charts/datadog/ci/apm-single-step-instrumentation-admission-controller-values.yaml
+++ b/charts/datadog/ci/apm-single-step-instrumentation-admission-controller-values.yaml
@@ -8,3 +8,16 @@ clusterAgent:
   enabled: true
   admissionController:
     enabled: true
+    targets:
+      - name: "example"
+        podSelector:
+          matchLabels:
+            language: "python"
+        namespaceSelector:
+          matchNames:
+            - "applications"
+        ddTraceVersions:
+          python: "v2"
+        ddTraceConfigs:
+          - name: "DD_PROFILING_ENABLED"
+            value: "true"
diff --git a/charts/datadog/templates/cluster-agent-deployment.yaml b/charts/datadog/templates/cluster-agent-deployment.yaml
index de82b3615..7386d767b 100644
--- a/charts/datadog/templates/cluster-agent-deployment.yaml
+++ b/charts/datadog/templates/cluster-agent-deployment.yaml
@@ -281,6 +281,10 @@ spec:
           - name: DD_APM_INSTRUMENTATION_LIB_VERSIONS
             value: {{ .Values.datadog.apm.instrumentation.libVersions | toJson | quote }}
           {{- end }}
+          {{- if .Values.datadog.apm.instrumentation.targets }}
+          - name: DD_APM_INSTRUMENTATION_TARGETS
+            value: {{ .Values.datadog.apm.instrumentation.targets | toJson | quote }}
+          {{- end }}
           {{- if .Values.datadog.apm.instrumentation.injector.imageTag }}
           - name: DD_APM_INSTRUMENTATION_INJECTOR_IMAGE_TAG
             value: {{ .Values.datadog.apm.instrumentation.injector.imageTag | quote }}
diff --git a/charts/datadog/values.yaml b/charts/datadog/values.yaml
index eda1f1a64..d889d1a39 100644
--- a/charts/datadog/values.yaml
+++ b/charts/datadog/values.yaml
@@ -530,6 +530,22 @@ datadog:
       # datadog.apm.instrumentation.libVersions -- Inject specific version of tracing libraries with Single Step Instrumentation (preview).
       libVersions: {}
 
+      # datadog.apm.instrumentation.targets -- Enable target based workload selection (preview).
+      # Requires Cluster Agent 7.64.0+
+      targets: []
+      #  - name: "example"
+      #    podSelector:
+      #      matchLabels:
+      #        language: "python"
+      #    namespaceSelector:
+      #      matchNames:
+      #      - "applications"
+      #    ddTraceVersions:
+      #      python: "v2"
+      #    ddTraceConfigs:
+      #      - name: "DD_PROFILING_ENABLED"
+      #        value: "true"
+
       # datadog.apm.instrumentation.skipKPITelemetry -- Disable generating Configmap for APM Instrumentation KPIs
       skipKPITelemetry: false