Web-based application as a supplement to the paper: "Number of life-years lost at the time of diagnosis and several years post-diagnosis in patients with solid malignancies: a population-based study in the Netherlands, 1989-2019"

Authors: Carolien C.H.M. Maas, David van Klaveren, Otto Visser, Prof Matthias A.W. Merkx, Prof Hester F. Lingsma, Prof Valery E.P.P. Lemmens, Avinash G. Dinmohamed

Background Loss of life expectancy (LOLE) may provide more intuitive information on the impact of cancer than relative survival over a fixed time horizon (e.g., 5-year relative survival). We aimed to assess the evolution of the LOLE using a nationwide, population-based cohort including patients diagnosed with one of 17 most frequent solid malignancies.

Methods From the Netherlands Cancer Registry, we selected adult patients diagnosed with one of the 17 most frequent solid malignancies in the Netherlands during 1989-2019, with survival follow-up until 2022. We used flexible parametric survival models to estimate the LOLE at diagnosis and the LOLE after surviving several years post-diagnosis (conditional LOLE; CLOLE) by cancer type, calendar year, age, sex, and disease stage.

Findings For all cancers combined, the LOLE consistently decreased from 1989 to 2019. This decrease was most pronounced for males with prostate cancer (e.g., from 6·9 [95% confidence interval [CI], 6·7-7·1] to 2·7 [95% CI, 2·5-3·0] for 65-year-olds) and females with breast cancer (e.g., from 6·6 [95% CI, 6·4-6·7] to 1·9 [95% CI, 1·8-2·0] for 65-year-olds). The LOLE among patients with cancers of the head and neck or the central nervous system remained constant over time. Overall, the CLOLE showed that the life years lost among patients with cancer decreased with each additional year survived post-diagnosis. For example, the LOLE at diagnosis for 65-year-old females diagnosed with breast cancer in 2019 was 1·9 [95% CI, 1·8-2·0] compared with 1·7 [95% CI, 1·6-1·8], 1·0 [95% CI, 0·9-1·1], and 0·5 [95% CI, 0·5-0·6] when surviving one, five, and ten years post-diagnosis, respectively. Estimates for other combinations of patient and tumour characteristics are available in a publicly available web-based application.

Interpretation The evolution of LOLE substantially varies across cancer type, age, and disease stage. LOLE estimates help patients better understand the impact of their specific cancer diagnosis on their life expectancy.

Funding None.

Calculator: https://mdmerasmusmc.shinyapps.io/LOLECalculator/