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Exploratory: compare R-loops with sites of chromosomal rearrangements and mutations #69

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millerh1 opened this issue Dec 16, 2021 · 0 comments
Open
2 tasks

Exploratory: compare R-loops with sites of chromosomal rearrangements and mutations #69

millerh1 opened this issue Dec 16, 2021 · 0 comments
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analysis needed This issue requires an analysis (e.g., Identification of gene expression changes with treatment) mid-priority

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@millerh1
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One area of interest is whether a particular subset of R-loops is associated with chromosomal rearrangements and mutations. Two interesting ways of exploring this question are:

  • Calculate the Class I/II ratio across all sites and then compare with sites of rearrangements / mutations. Do we see an increase with either type?
  • Compare R-loop consensus sites with chromosomal rearrangement and mutation sites -- do we see a particular subset of R-loops enriched?
@millerh1 millerh1 added the analysis needed This issue requires an analysis (e.g., Identification of gene expression changes with treatment) label Dec 16, 2021
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analysis needed This issue requires an analysis (e.g., Identification of gene expression changes with treatment) mid-priority
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